Human-Derived
ASCE+ SRLV
ASCE+ range human-derived exosome for visible skin rejuvenation, pore appearance, and firmness support.
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Hanheal Exosome Facial Rejuvenation
A dual-component professional skin booster from BNC Global Korea Ltd. Built around multipotent cellular exosomes derived from human dermal fibroblasts, combined with sodium hyaluronate and a nutrient-rich activator ampoule. Used in professional aesthetic settings for skin hydration, texture refinement, elasticity support, and post-procedure recovery workflows.
Hydration Skin Texture Elasticity Radiance Post-Procedure Mesotherapy
Product Overview
What Is Hanheal Exosome Facial Rejuvenation?
Hanheal is BNC Global's professional exosome skin booster, developed for intradermal delivery in clinic settings. The product runs on a two-component system: a freeze-dried powder vial containing the exosome payload and a liquid activator ampoule containing supporting actives. The two are mixed immediately before use to preserve exosome bioactivity.
The exosomes are multipotent cellular exosomes derived from human dermal fibroblasts — the cells responsible for producing collagen and elastin in skin. This is a meaningful distinction from products that source exosomes from adipose stem cells or plant cultures. The activator ampoule delivers sodium hyaluronate alongside a range of brightening, hydrating, and skin-quality actives. Full ingredient detail is covered in the Formulation section below.
Hanheal sits within the human-derived exosome skin booster category alongside ASCE+ SRLV. Its key differentiator within this range is the human dermal fibroblast exosome source and the dual-component format with a nutrient-rich activator.
Regulatory Note: Hanheal Exosome Facial Rejuvenation is a professional aesthetic product manufactured by BNC Global Korea Ltd. It is not a pharmaceutical. It has not received FDA, EMA, or equivalent drug regulatory approval. There are currently no FDA-approved exosome products of any kind. For professional clinic use only.
Key Highlights
Product Characteristics
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Human Dermal Fibroblast Exosomes — The exosome source here is human dermal fibroblasts — the skin's primary collagen- and elastin-producing cells. This source type is studied for its relevance to skin repair, cellular communication, and regenerative signalling in dermal tissue.
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Sodium Hyaluronate Carrier — Sodium hyaluronate acts as the humectant carrier within the activator vial. It supports moisture retention, improves skin plumpness, and helps facilitate dermal delivery of the exosome payload.
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Nutrient-Rich Activator Ampoule — The liquid activator vial contains additional actives documented across product literature: niacinamide (brightening, pore-refinement), glutathione (antioxidant), hydrolysed collagen, copper tripeptide-1, tranexamic acid, adenosine, biotin, polynucleotide, and over 20 amino acids.
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Dual-Component Lyophilized Format — Freeze-drying the exosome powder until the point of use preserves full bioactivity. The components are mixed immediately before injection — the same approach used in premium professional exosome products to avoid degradation in storage.
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Intradermal & Microneedling Compatible — Administered intradermally using a mesotherapy gun, hydra pen, or microneedling device at 0.2–2.0 mm depth, using 30G or 32G needles. Also compatible with post-microneedling topical application protocols.
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BNC Global Korea Ltd. — Manufactured by BNC Global Korea Ltd. in South Korea. Produced under Korean MFDS cosmetic and aesthetic product standards for professional use.
Formulation
Actives & Formulation Notes
Hanheal uses a two-component system. Ingredients are separated to protect exosome integrity until the moment of reconstitution. Key actives per publicly available formulation data:
Component 1 — Lyophilized Exosome Powder (Dry Ampoule, 100 mg × 5)
- •Multipotent cellular exosomes derived from human dermal fibroblasts
- •Lyophilized (freeze-dried) to preserve bioactivity through storage
Component 2 — Liquid Activator Ampoule (5 ml × 5)
- •Sodium hyaluronate — humectant carrier, hydration and delivery support
- •Niacinamide — brightening, pore-refinement, anti-inflammatory
- •Glutathione — antioxidant, skin clarity support
- •Hydrolysed collagen — structural and hydration support
- •Copper tripeptide-1 — wound healing and barrier support
- •Tranexamic acid — hyperpigmentation and uneven tone
- •Adenosine — anti-ageing, skin repair
- •Biotin — skin health support
- •Polynucleotide — tissue repair and hydration
- •20+ amino acids — building blocks for skin protein synthesis
Formulation note: Full INCI list and concentration data should be confirmed with BNC Global manufacturer documentation before clinical use. The above reflects publicly available product literature. Batch specifications may vary. Some resellers describe different ampoule combinations — always reference official BNC Global product documentation for the variant you are sourcing.
Protocol Context
How Clinicians Use Hanheal
Intradermal Mesotherapy
The primary delivery method. Reconstituted solution is drawn into a sterile syringe and administered intradermally using nappage or maculopapular technique at 0.25–2 mm depth, 30G or 32G needle. Targets the dermis directly to support localised skin quality.
Post-Microneedling Application
Applied topically immediately after microneedling while temporary microchannels are open. The rationale is enhanced penetration of the exosome payload through the disrupted barrier. This is an emerging professional workflow — not settled clinical consensus.
Standalone Skin Booster Programme
Used as a standalone skin booster in dedicated hydration, radiance, or anti-ageing programmes. Typically structured across 3–5 sessions, building progressive skin quality improvement across the course.
Post-Laser and Post-RF Recovery
Positioned by some practitioners for use after laser resurfacing or RF treatments to support the recovery phase. Post-procedure application protocols should be confirmed with manufacturer documentation and practitioner clinical judgment.
Standard protocol: 3–5 clinical sessions spaced 2–4 weeks apart. Some clinical protocols use 5–10 sessions at 14-day intervals for more intensive courses. Maintenance: 1 session every 2–3 months after the initial course. Confirm with manufacturer protocol documentation.
Indicated Applications
Hanheal is used in professional aesthetic settings for the following skin concerns:
Primary Use Cases
- •Visible fine lines and skin laxity
- •Skin dehydration and dullness
- •Uneven skin texture and enlarged pores
- •Sun-damaged skin requiring tone and texture support
- •Age spots and mild pigmentation
- •Post-procedure skin recovery support
Treatment Areas
- •Face (primary)
- •Neck and décolleté
- •Hands
- •Body (where appropriate per practitioner)
Contraindications
The following contraindications apply per BNC Global product documentation. Practitioners should conduct a full patient assessment and review manufacturer guidelines before treatment.
- •Active eczema or severe active dermatitis in the treatment area
- •Open dermal wounds or damaged skin at the injection site
- •Pregnancy or breastfeeding
- •Autoimmune diseases
- •Diabetes
- •Infections or active illness at the time of treatment
- •Epilepsy
- •Patients under 18 years of age
- •Individual intolerance to any component of the formulation
COMPARISON CONTEXT
Hanheal vs Plant-Based Exosome Products
Professional buyers frequently ask how human-derived products like Hanheal compare with plant-based products like EXO NAD+ or LXC. The key differences are source type and the resulting biological profile — not quality or potency in any absolute sense.
Hanheal (Human-Derived)
- Exosomes from human dermal fibroblasts
- Growth factor profile aligned to human skin biology
- Draws from regenerative medicine and wound-healing research
- Dual-component: exosomes + nutrient ampoule
- Broader range of supporting actives in activator vial
- Higher ethical complexity vs plant-derived
Plant-Based Products (e.g. EXO NAD+)
- Exosomes from botanical stem cell cultures
- Antioxidant and anti-inflammatory cargo profile
- Typically simpler regulatory positioning
- Often multi-active in a single format
- Lower immunogenicity concern in some contexts
- Standardization remains an open area
Neither category is FDA-approved. The choice between human-derived and plant-based exosome products should be guided by practitioner clinical context, patient profile, and market regulatory requirements in the destination country.
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View ProductQuestions About Hanheal
Hanheal's exosomes are multipotent cellular exosomes derived from human dermal fibroblasts — the cells that produce collagen and elastin in skin. They are not stem cell-conditioned media (a common mischaracterisation). Dermal fibroblast-derived exosomes carry a signalling profile relevant to skin structural support, repair, and intercellular communication.
The liquid activator vial reconstitutes the dry exosome powder and delivers additional actives including sodium hyaluronate, niacinamide, glutathione, hydrolysed collagen, copper tripeptide-1, tranexamic acid, adenosine, biotin, polynucleotide, and over 20 amino acids. The exact formulation should be confirmed with official BNC Global product documentation for the specific variant sourced.
Reconstituted solution is administered intradermally using a mesotherapy gun, hydra pen, or microneedling device at 0.2–2.0 mm depth with 30G or 32G needles. Nappage or maculopapular injection technique is standard. Treatment areas include the face, neck, décolleté, and hands. Always follow manufacturer protocol documentation.
The standard course per manufacturer guidance is 3–5 sessions spaced 2–4 weeks apart. Some practitioners use more intensive protocols of 5–10 sessions at 14-day intervals for visible cumulative improvement. Maintenance is typically one session every 2–3 months after the initial course. Individual practitioner protocols and patient response will vary.
Both are human-derived exosome professional skin rejuvenation products. Hanheal uses exosomes from human dermal fibroblasts (BNC Global Korea). ASCE+ SRLV uses exosomes from human adipose tissue-derived stem cells (ExoCoBio, via their ExoSCRT technology). The source cell type, manufacturer, extraction technology, and supporting actives differ between the two. Both carry no FDA approval. Practitioner preference and clinic protocol context typically guide the choice.
No. Hanheal Exosome Facial Rejuvenation is a professional-only product supplied exclusively to verified clinics, aesthetic practitioners, and wholesale partners. It is not sold for home consumer use. Clinic and wholesale enquiries are handled through the Contact / Wholesale page.