Human-Derived Skin Rejuvenation
ASCE+ SRLV
Human-derived injectable exosome skin rejuvenation product by ExoCoBio Inc. Human adipose MSC exosomes via ExoSCRT™ technology for professional skin quality protocols.
View Product Human-Derived Skin Rejuvenation Tone & Brightening
GTM Exomela Skin Booster
Human-derived exosome skin booster for professional skin tone and brightening protocols, manufactured by GTM Cosmetic / CMED Co., Ltd (Seoul, South Korea). A dual-component lyophilised system: Exo Signal 1000 Powder containing human dermal fibroblast-induced multipotent cell culture conditioned media, reconstituted with Mela Vital Solution enriched with PDRN, tranexamic acid, and peptides. Positioned for practitioners addressing uneven tone, post-inflammatory pigmentation concerns, and overall skin clarity within professional aesthetic workflows.
Professional use product. No exosome products are currently FDA-approved. Claims reflect emerging scientific literature and professional use context; individual outcomes vary and are not guaranteed.
Product Overview
What Is GTM Exomela Skin Booster?
GTM Exomela Skin Booster is manufactured by CMED Co., Ltd, a Seoul-based company that trades under the GTM Cosmetic brand. It belongs to GTM's Exosome Solution line alongside GTM Exoshine (skin firming and radiance) and GTM Exoscalp (scalp care). All three products share the same freeze-dried Exo Signal 1000 Powder base, differentiated by their companion active solution.
The Exo Signal 1000 Powder contains lyophilised conditioned media from human dermal fibroblast-induced multipotent cells — the exosome source throughout the GTM range. The 5 ml Mela Vital Solution carries the tone-targeted actives: PDRN, tranexamic acid, and peptides. The two components are reconstituted immediately before use.
Exomela's positioning is tone, clarity, and brightening in professional aesthetic practice. Tranexamic acid is an established brightening active with a documented mechanism of action at the melanin pathway. PDRN provides the tissue support and hydration base that appears across this product family. The conditioned media component adds the cellular signalling profile common to the GTM Exosome line.
Regulatory note: There are currently no FDA-approved exosome products. GTM Exomela Skin Booster is a professional aesthetic product, not a pharmaceutical. It is not indicated for, nor approved to treat, any diagnosed pigmentation disorder including melasma or post-inflammatory hyperpigmentation. Evidence for exosome conditioned media in skin tone contexts is at an early investigational stage. For professional use only.
Formulation & Product Characteristics
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Exo Signal 1000 Powder — Human Dermal Fibroblast-Derived Conditioned Media
The lyophilised powder across the GTM Exosome line uses conditioned media from human dermal fibroblast-induced multipotent cells. 180 mg per vial for Exomela. This is the exosome and cellular signalling component shared with Exoshine and Exoscalp, differentiated by the companion solution.
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Mela Vital Solution — PDRN + Tranexamic Acid + Peptides
The Mela Vital Solution (5 ml) is the tone-targeted reconstitution solution specific to Exomela. It contains PDRN for tissue support and hydration, tranexamic acid for its brightening mechanism, and peptides. This differentiates Exomela from Exoshine (Shine Glow Solution: PDRN and peptides) and Exoscalp (Scalp Renew Solution: peptides and panthenol).
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Tranexamic Acid — Brightening Active
Tranexamic acid is an antifibrinolytic compound with a documented mechanism of action relevant to melanin production — it competitively inhibits the binding of plasminogen to keratinocytes, reducing UV-induced prostaglandin release and downstream melanocyte activation. It is one of the better-evidenced topical brightening actives in Korean professional skin booster formulations.
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PDRN — Tissue Support & Hydration Base
Polydeoxyribonucleotide (PDRN) is an established active in the Korean professional injectable skin booster category with a relatively substantial aesthetic medicine literature base. It provides the moisture and tissue support component of the formulation alongside the tone-targeting actives.
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GTM Cosmetic / CMED Co., Ltd, Seoul
Legal manufacturer: CMED Co., Ltd, 5F, 101 Ogeumro, Songpa-gu, Seoul. Business registration: 298-88-00658. The GTM Exosome line (Exomela, Exoshine, Exoscalp) is manufactured at their Hanam-si, Gyeonggi-do facility. GTM Cosmetic is the brand trading name.
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Dual-Component Lyophilised Format
Each box contains 5 sets of Exo Signal 1000 Powder (180 mg) + Mela Vital Solution (5 ml). Powder is freeze-dried for bioactivity preservation and reconstituted immediately before use. Same format across the GTM Exosome range; the difference between products sits in the active solution.
How GTM Exomela Fits Professional Aesthetic Practice
GTM Exomela sits in the tone and brightening segment of the Korean professional skin booster category. Its combination of exosome conditioned media, tranexamic acid, and PDRN makes it suited to workflows targeting uneven tone, post-inflammatory marks, and overall skin clarity — typically as part of combination programmes with energy-based devices or post-procedure recovery protocols.
Best-Fit Use Cases
- •Uneven skin tone and brightening protocols
- •Post-inflammatory hyperpigmentation support
- •Post-laser or post-IPL skin quality maintenance
- •Combination tone programmes with chemical peels
- •Skin clarity and texture improvement workflows
- •Standalone skin booster sessions — tone focus
Related Treatment Contexts
- •Korean professional skin booster workflows
- •Combination with laser / IPL tone management
- •Post-procedure skin quality support
- •Human-derived exosome aesthetic protocols
- •Regenerative aesthetics — tone and clarity focus
- •Comparison with plant-based brightening options (e.g. EXOCODE Radiance-R)
Formulation
Active Ingredients — What's Actually in GTM Exomela
GTM Exomela uses a dual-component reconstitution system. The two components are combined immediately before use to preserve conditioned media bioactivity.
Exo Signal 1000 Powder — 180 mg Lyophilised
- •Human dermal fibroblast-induced multipotent cell culture conditioned media — lyophilised exosome and cellular signalling component
- •Freeze-dried for bioactivity preservation until reconstitution
- •180 mg per vial (Exomela-specific quantity; Exoshine uses 1000 mg per vial)
Mela Vital Solution — 5 ml
- •PDRN (polydeoxyribonucleotide) — tissue support, hydration, and skin quality base
- •Tranexamic acid — brightening active targeting melanin pathway
- •Peptides — supporting skin quality and firmness
- •Additional solvent actives to confirm with manufacturer INCI documentation
Formulation note: Full INCI list including carrier components, peptide identities, and PDRN concentration should be confirmed with GTM Cosmetic / CMED Co., Ltd manufacturer documentation before clinical use. The above reflects verified publicly available specification data from the manufacturer's own product page.
How Clinicians Use GTM Exomela
Mesotherapy (Intradermal Injection)
The primary delivery method for the GTM Exosome range is intradermal mesotherapy injection. The reconstituted solution is administered at intradermal depth using standard mesotherapy technique. Deliver into target areas across the treatment zone.
Post-Microneedling Topical Application
Applied topically immediately after microneedling while microchannels are temporarily open, allowing penetration of the reconstituted solution. This workflow is common across Korean professional skin booster products. Suitable for combination sessions targeting tone and skin quality simultaneously.
Combination with Laser and IPL
Most frequently used alongside laser (Q-switched Nd:YAG, picosecond, IPL) tone management treatments. The PDRN and tranexamic acid combination supports post-laser skin quality while the tone-targeting actives address residual pigmentation concerns within the same protocol.
Recommended protocol: 3–5 sessions at 2–4 week intervals for an initial course, with maintenance sessions thereafter. Each box contains 5 sets, covering a standard initial course. Confirm exact protocol, needle gauge, and injection depth with practitioner clinical judgment and manufacturer guidelines.
Specification Summary
Product Specification
Related Products
The wider human-derived skin rejuvenation range and the plant-based tone alternative.
Human-Derived Skin Rejuvenation
Hanheal Exosome Facial Rejuvenation
Premium human-derived exosome concentrate for skin hydration, texture, radiance, and elasticity in professional clinic settings.
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Plant-Based Skin Rejuvenation
EXOCODE Radiance-R
Plant-based topical tone alternative by ExoCoBio Inc. Rosa Damascena EVs + tranexamic acid, niacinamide, Nonapeptide-1. Topical only — not injectable.
View ProductGTM Exomela Questions
The Exo Signal 1000 Powder uses conditioned media from human dermal fibroblast-induced multipotent cells — lyophilised and freeze-dried. This is consistent across the GTM Exosome range (Exomela, Exoshine, Exoscalp). Some resellers describe the source as human adipose stromal cells; the manufacturer's own product pages specify human dermal fibroblast-induced multipotent cell culture conditioned media. Verify with CMED Co., Ltd documentation before clinical use.
Both use the same Exo Signal 1000 Powder base (human dermal fibroblast conditioned media). The difference is in the companion active solution. Exomela uses Mela Vital Solution (PDRN + tranexamic acid + peptides) — targeting tone and brightening. Exoshine uses Shine Glow Solution (PDRN + peptides, 1000 mg powder per set) — positioned for overall skin firming and radiance without the dedicated brightening active.
Tranexamic acid competitively inhibits plasminogen binding to keratinocytes, reducing the UV-induced prostaglandin release that drives melanocyte activation and melanin production. It is one of the better-supported topical brightening actives in Korean professional skin booster formulations, with a clearer mechanism of action than arbutin or some other whitening agents.
No. GTM Exomela is a professional aesthetic product, not a pharmaceutical treatment. It cannot be described as treating, curing, or preventing any diagnosed pigmentation condition including melasma or post-inflammatory hyperpigmentation. Its positioning is tone, clarity, and brightening support within professional aesthetic workflows. Claims must remain within this framing.
The two products represent different approaches. GTM Exomela is human-derived (dermal fibroblast conditioned media) and injectable or post-microneedling topical, with PDRN and tranexamic acid as the key tone actives. EXOCODE Radiance-R (ExoCoBio) is plant-based (Rosa Damascena callus EVs), topical only (not injectable), and uses tranexamic acid, niacinamide, and dipotassium glycyrrhizate for its tone positioning. Different cell sources, delivery routes, and manufacturer technology platforms.
GTM Exomela is available for professional clinic purchase and wholesale distribution orders. Contact Exosome Korea via the Contact / Wholesale page to discuss availability, pricing, and minimum order quantities.