Human-Derived Skin Rejuvenation
ASCE+ SRLV
ExoCoBio's human-derived injectable exosome product for professional skin rejuvenation. Same manufacturer as EXOCODE Radiance-R — injectable vs topical.
View Product Plant-Based Skin Rejuvenation EXOCODE Range
EXOCODE Radiance-R
TOPICAL ONLY — NOT INJECTABLE
Plant-based topical exosome treatment for professional skin radiance and tone protocols, developed by ExoCoBio Inc. (Seoul, South Korea). A two-ampoule system combining Rosa Damascena callus extracellular vesicles and 6 recombinant growth factors (Ampoule 1 / Core Solution) with a tone-targeted active solution containing tranexamic acid, niacinamide, dipotassium glycyrrhizate, and two peptides (Ampoule 2 / Radiance-R Solution). Topical application only — not injectable. Part of the EXOCODE range alongside EXOCODE Resilience-R.
Professional use product. No exosome products are currently FDA-approved. Claims reflect emerging scientific literature and professional use context; individual outcomes vary and are not guaranteed.
Product Overview
What Is EXOCODE Radiance-R?
EXOCODE Radiance-R is a two-ampoule topical professional skin treatment from ExoCoBio Inc. The same manufacturer produces ASCE+ SRLV (human-derived injectable, skin rejuvenation), ASCE+ HRLV Hair (plant-based injectable, scalp — Rosa Damascena Callus EVs via ExoSCRT™ RSCE™), EXOCODE Resilience-R (plant-based topical, elasticity focus), and the EXOCODE line is built on ExoCoBio's ExoSCRT™ isolation technology applied to Rosa Damascena callus cultures.
Both EXOCODE products share an identical Ampoule 1 (Core Solution): Rosa Damascena Callus Extracellular Vesicles and 6 recombinant growth factors in a 2 ml base. The differentiation sits entirely in Ampoule 2. Radiance-R's solution (3 ml) carries tranexamic acid, niacinamide, dipotassium glycyrrhizate, Palmitoyl Tetrapeptide-7, and Nonapeptide-1 — all targeted at skin tone, melanin regulation, and brightening. Resilience-R's solution carries sodium hyaluronate, elastin, dexpanthenol, DMAE, copper tripeptide-1, and Palmitoyl Pentapeptide-4 — targeted at elasticity and firmness.
The product is topical only. It is applied to the skin surface and not administered by injection. This places it in a different protocol category from injectable skin boosters like ASCE+ SRLV or GTM Exomela, and means it sits outside the injectable exosome regulatory concerns that have driven FDA enforcement activity.
Regulatory note: There are currently no FDA-approved exosome products. EXOCODE Radiance-R is a professional topical aesthetic product, not a pharmaceutical. It is not approved to treat, cure, or prevent any diagnosed pigmentation condition. Evidence for plant-derived exosome applications is at an investigational stage. For professional use only.
Formulation & Product Characteristics
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Rosa Damascena Callus Extracellular Vesicles — ExoSCRT™
The exosome source is the callus culture of Rosa Damascena (Damask rose), isolated using ExoCoBio's ExoSCRT™ proprietary tangential flow filtration process. The same Rosa Damascena callus EV base is used in both Resilience-R and Radiance-R. ExoCoBio holds a US patent for the RSCE™ technology and INCI registration with the PCPC (2020).
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6 Recombinant Growth Factors in the Core Solution
Ampoule 1 contains: EGF (sh-Oligopeptide-1), IGF-1 (sh-Oligopeptide-2), bFGF (sh-Polypeptide-1), KGF (sh-Polypeptide-3), TGF-β1 (sh-Polypeptide-4), VEGF (sh-Polypeptide-9). These 6 growth factors are identical to those in the Resilience-R Core Solution — the two products share this ampoule.
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Radiance-R Solution — Tone & Brightening Active Combination
Ampoule 2 contains tranexamic acid (melanin pathway inhibitor), niacinamide (vitamin B3, brightening and barrier support), dipotassium glycyrrhizate (licorice-derived, tone-evening), Palmitoyl Tetrapeptide-7 (anti-inflammatory peptide), and Nonapeptide-1 (targets α-MSH receptor to reduce melanin stimulation). This is the ingredient combination that distinguishes Radiance-R from Resilience-R.
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Topical Only — Not Injectable
Both EXOCODE products are applied topically, not administered by injection. The protocol is post-microneedling topical application or use alongside energy-based devices. This differentiates the EXOCODE range from the ASCE+ injectable range within the ExoCoBio product family.
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Compatible with RF Microneedling, Nd:YAG, HIFU
Designed for combination with energy-based device protocols. The two-ampoule contents are mixed immediately before use and applied to the treatment area following the procedure. Compatible with the same device types as Resilience-R.
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ExoCoBio Inc., Seoul
ExoCoBio also manufactures ASCE+ SRLV (human-derived, injectable, skin rejuvenation), ASCE+ HRLV Hair (plant-based, injectable, scalp — Rosa Damascena Callus EVs), and EXOCODE Resilience-R (plant-based topical, elasticity). EXOCODE Radiance-R is the tone and radiance variant in the plant-based topical range.
Range Context
Radiance-R vs Resilience-R — The EXOCODE Range
The EXOCODE range runs on a modular two-ampoule architecture. Ampoule 1 is identical across the range. Ampoule 2 defines the clinical focus. This table shows how the two current EXOCODE products relate:
How EXOCODE Radiance-R Fits Professional Aesthetic Practice
EXOCODE Radiance-R sits in the plant-based topical exosome segment alongside products like EXO NAD+ and LXC Lacto Exo Colla, but with a narrower focus on tone and radiance rather than broad skin renewal. Its combination of Rosa Damascena EVs with dedicated brightening actives (tranexamic acid, niacinamide, Nonapeptide-1) makes it the most targeted brightening option in the plant-based range on this site.
Best-Fit Use Cases
- •Post-procedure radiance and tone support
- •Dullness and uneven tone protocols
- •Post-laser or post-IPL skin quality maintenance
- •Combination with RF microneedling for tone
- •Plant-based alternative to injectable tone boosters
- •Skin brightening programmes without injectables
Related Treatment Contexts
- •Korean plant-based exosome workflows
- •Post-energy device topical application
- •Combination with EXOCODE Resilience-R (tone + firmness)
- •Comparison with GTM Exomela (human-derived, injectable)
- •Regenerative aesthetics — radiance and surface quality
- •Practitioners preferring topical-only protocols
Formulation
Complete INCI — What's Actually in EXOCODE Radiance-R
EXOCODE Radiance-R is a two-ampoule system. Mix the contents of Ampoule 1 (Core Solution, 2 ml) into Ampoule 2 (Radiance-R Solution, 3 ml) immediately before use. Total reconstituted volume: 5 ml.
Ampoule 1 — EXOCODE Core Solution (2 ml) — SHARED WITH RESILIENCE-R
Ampoule 2 — EXOCODE Radiance-R Solution (3 ml) — RADIANCE-R SPECIFIC
Formulation note: INCI lists confirmed from multiple independent reseller sources and cross-referenced against ExoCoBio range documentation. Full batch-specific INCI and concentration data should be verified with ExoCoBio Inc. manufacturer documentation before clinical use.
How Clinicians Use EXOCODE Radiance-R
Post-Microneedling Topical Application
Applied topically to the treatment area immediately after microneedling while microchannels are temporarily open. The combined ampoule solution is distributed across the skin surface and allowed to absorb. The same protocol applies to Resilience-R. No injection required.
Combination with Energy-Based Devices
Compatible with RF microneedling, Nd:YAG laser, and HIFU. Applied topically following the procedure in the same session. The Rosa EVs, growth factors, and brightening actives address both post-treatment recovery and the radiance / tone concern simultaneously.
Combination Protocol with Resilience-R
Some practitioners run Radiance-R and Resilience-R in sequence or alternating sessions to address both tone and elasticity within the same programme. Both products are topical, share the same Core Solution, and are compatible with the same device types.
Recommended protocol: 3 sessions at 3–4 week intervals for an initial course. Mix Ampoule 1 (Core Solution) into Ampoule 2 (Radiance-R Solution) immediately before use. Apply combined solution to face and allow complete absorption. Confirm protocol with manufacturer guidelines and practitioner clinical judgment.
Specification Summary
Product Specification
Related Products
The wider ExoCoBio range and the plant-based skin rejuvenation alternatives.
Human-Derived Skin Rejuvenation
GTM Exomela
Human-derived injectable tone booster with PDRN and tranexamic acid. The injectable counterpart for practitioners comparing tone approaches.
View Product
Plant-Based Skin Rejuvenation
EXO NAD+
Korea's flagship plant-based all-in-one exosome skin rejuvenating solution with NAD+ for renewal and vitality support.
View ProductEXOCODE Radiance-R Questions
Both products share an identical Ampoule 1 (Core Solution): Rosa Damascena Callus Extracellular Vesicles and 6 growth factors in 2 ml. The Ampoule 2 is what separates them. Radiance-R's solution carries tranexamic acid, niacinamide, dipotassium glycyrrhizate, Palmitoyl Tetrapeptide-7, and Nonapeptide-1 — targeting tone and brightening. Resilience-R's solution carries sodium hyaluronate, elastin, dexpanthenol, DMAE, copper tripeptide-1, and Palmitoyl Pentapeptide-4 — targeting elasticity and firmness. Same base, different clinical focus.
Rosa Damascena Callus Extracellular Vesicles, isolated from Damask rose callus cultures using ExoCoBio's ExoSCRT™ tangential flow filtration technology. These are plant-derived extracellular vesicles, not human-derived. They are distinct from the human adipose MSC exosomes used in ASCE+ SRLV and from the human dermal fibroblast conditioned media used in GTM Exomela.
No. Both EXOCODE products are topical only. The mixed solution is applied to the skin surface after microneedling or energy-based device treatment and allowed to absorb. There is no injection. This places them in a different delivery and regulatory category from injectable skin boosters in the range.
Nonapeptide-1 is a synthetic peptide that acts as a competitive antagonist at the α-MSH (alpha-melanocyte stimulating hormone) receptor on melanocytes. By blocking α-MSH binding, it reduces the signalling cascade that triggers melanin production. It works alongside tranexamic acid (which targets the plasminogen / prostaglandin pathway upstream) and niacinamide (which inhibits melanosome transfer to keratinocytes) to address the melanin pathway at multiple points.
Different approaches across several dimensions. Radiance-R is plant-based (Rosa Damascena EVs), topical only, and uses tranexamic acid, niacinamide, dipotassium glycyrrhizate, and Nonapeptide-1. GTM Exomela is human-derived (dermal fibroblast conditioned media), injectable or post-microneedling topical, and uses PDRN, tranexamic acid, and peptides. Practitioners preferring a topical-only protocol with a plant-based exosome source would lean toward Radiance-R; those wanting injectable delivery or the PDRN component would lean toward Exomela.
Yes. RF microneedling is one of the primary compatible device types listed for the EXOCODE range alongside Nd:YAG and HIFU. The mixed solution is applied topically immediately after the procedure in the same session.
EXOCODE Radiance-R is available for professional clinic purchase and wholesale distribution orders. Contact Exosome Korea via the Contact / Wholesale page to discuss availability, pricing, and minimum order quantities.