Plant-Based
EXOCODE Radiance - R
Exocode range plant-based exosome for radiance and uneven skin tone. Same exosome source, different Ampoule 2 actives targeting brightening.
View Product Plant-Based Skin Rejuvenation Damask Rose Exocode Range
EXOCODE Resilience - R
A professional two-ampoule topical exosome treatment from ExoCoBio Inc. (Seoul, South Korea). EXOCODE Resilience - R was developed specifically for skin that has lost elasticity, targeting firmness and resilience improvement. The formulation pairs Rosa Damascena Callus Extracellular Vesicles (Damask rose plant exosomes, extracted using ExoCoBio's proprietary ExoSCRT™ technology) with six recombinant growth factors in Ampoule 1, and a targeted elasticity active complex in Ampoule 2.
ElasticityFirmnessResilienceRosa DamascenaExoSCRT™Growth FactorsExoCoBio
Product Overview
What Is EXOCODE Resilience - R?
EXOCODE is ExoCoBio's professional plant-exosome product line — positioned alongside their ASCE+ human-derived range for different clinical contexts. Where ASCE+ SRLV uses adipose stem cell-derived exosomes, EXOCODE uses plant exosomes from Damask rose (Rosa damascena), extracted and purified using ExoCoBio's ExoSCRT™ technology.
Within the EXOCODE line, each product variant addresses a specific skin concern. Resilience-R targets elasticity and firmness. Radiance-R (a separate product) targets dull, grey, or uneven-toned skin. The "R" suffix in both names stands for "rose" — the shared botanical exosome source. The clinical application is what differs.
The two-ampoule system separates the exosome-and-growth-factor payload (Ampoule 1) from the elasticity-focused active complex (Ampoule 2). Contents are mixed immediately before topical application. The product is applied to the face and allowed to absorb, compatible with several energy-based device modalities.
Regulatory note: EXOCODE Resilience - R is a professional aesthetic product manufactured by ExoCoBio Inc. It is not a pharmaceutical. It has not received FDA, EMA, or equivalent drug regulatory approval. There are currently no FDA-approved exosome products. For professional clinic use only.
Key Highlights
The Exosome Source — What Sets EXOCODE Apart
ExoCoBio developed ExoSCRT™ (Exosome based SCReen Technology) as a proprietary isolation and purification platform. It mass-cultures plant stem cells and uses this technology to separate and purify high-purity exosomes — rather than simply extracting vesicles from plant juice, which is how simpler plant exosome products work.
ExoCoBio fact: ExoCoBio obtained a US patent for their Rose Stem Cell-derived Exosome (RSCE™) technology. Analysis of RSCE™ found it contains approximately 200 types of miRNAs and more than 90 types of proteins, some of which are similar to those found in humans. ExoCoBio registered Rosa Damascena Callus Extracellular Vesicles as a cosmetic ingredient (INCI name) with the Personal Care Products Council (PCPC) in the United States in 2020. Source: ExoCoBio press release, May 2023.
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Rosa Damascena Callus Extracellular Vesicles — Exosomes from Damask rose stem cell callus culture — not simple juice extraction. Rosa damascena is documented to contain polyphenols, flavonoids, and bioactive terpenoids including citronellol (30–40%) and geraniol (20–30%), with antioxidant activity. The callus culture approach standardises vesicle production and purity, unlike whole-plant extraction methods.
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ExoSCRT™ Purification — ExoCoBio's proprietary isolation and purification technology. Produces standardised, high-purity exosomes with defined particle characteristics. The same ExoSCRT™ platform is used for ExoCoBio's ASCE+ human-derived exosome products, providing manufacturing consistency across the product family.
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Six Growth Factors in the Core Solution — Ampoule 1 carries Rosa Damascena exosomes alongside six recombinant growth factors. This dual payload — botanical vesicles plus targeted growth factor proteins — is a differentiating feature of the EXOCODE range versus simpler single-active plant exosome products.
Formulation
Complete Ingredient Breakdown — Both Ampoules
Full INCI list per publicly available ExoCoBio product documentation and verified distributor listings:
Ampoule 1 — EXOCODE Core Solution (2 ml)
Contains the Rosa Damascena exosomes and six recombinant growth factors:
| INCI Name | Common Name | Function / Role |
|---|---|---|
| Rosa Damascena Callus Extracellular Vesicles | Damask Rose Exosomes | Plant-origin exosomes via ExoSCRT™ purification; primary active |
| sh-Oligopeptide-1 | EGF (Epidermal Growth Factor) | Stimulates epidermal cell proliferation; skin renewal and repair |
| sh-Oligopeptide-2 | IGF-1 (Insulin-like Growth Factor 1) | Supports fibroblast activity; collagen and elastin production |
| sh-Polypeptide-1 | bFGF (basic Fibroblast Growth Factor) | Fibroblast proliferation; extracellular matrix synthesis; elasticity |
| sh-Polypeptide-3 | KGF / FGF-7 (Keratinocyte Growth Factor) | Keratinocyte proliferation; skin repair and wound healing |
| sh-Polypeptide-4 | TGF-β1 (Transforming Growth Factor Beta 1) | Collagen synthesis regulation; tissue remodelling |
| sh-Polypeptide-9 | VEGF (Vascular Endothelial Growth Factor) | Angiogenesis; nutrient delivery; overall skin vitality support |
| Water, Sodium Chloride, Sodium Phosphate, Disodium Phosphate | Buffer and carrier | Physiological buffer system maintaining solution stability |
Ampoule 2 — EXOCODE Resilience-R Solution (3 ml)
Contains the elasticity-specific active complex that differentiates Resilience-R from Radiance-R:
| INCI Name | Common Name | Function / Role |
|---|---|---|
| Sodium Hyaluronate | Hyaluronic Acid | Humectant; hydration and delivery carrier |
| Elastin | Elastin protein | Structural protein for skin elasticity; declines with age; direct replenishment |
| Dexpanthenol | Panthenol (Pro-Vitamin B5) | Moisturising; skin barrier protection; prevents trans-epidermal water loss |
| Dimethylaminoethanol Tartrate | DMAE | Skin health and elasticity support; protection from external aggressors |
| Copper Tripeptide-1 | GHK-Cu | Wound healing; barrier support; collagen synthesis co-factor |
| Palmitoyl Pentapeptide-4 | Matrixyl | Collagen synthesis stimulation; anti-wrinkle; one of the most studied aesthetic peptides |
| Water, Sodium Chloride, Sodium Phosphate, Sodium Bicarbonate | Buffer and carrier | Physiological buffer system maintaining solution stability and pH |
Formulation note: The above INCI data is verified against ExoCoBio product documentation and multiple authorised distributor listings. Full technical data sheets should be confirmed with ExoCoBio or authorised distributors before clinical use. This is a topical product — not an injectable. Do not administer via intradermal injection.
Resilience-R vs Radiance-R — Critical Distinction
Two Products, Same Exosome Source, Different Ampoule 2
Both EXOCODE Resilience-R and EXOCODE Radiance-R share the same Ampoule 1 (EXOCODE Core Solution — Rosa Damascena exosomes + six growth factors). The difference is entirely in Ampoule 2, which contains the concern-specific actives.
EXOCODE RESILIENCE-R (THIS PRODUCT)
- Ampoule 2: Sodium Hyaluronate, Elastin, DMAE, Copper Tripeptide-1, Palmitoyl Pentapeptide-4
- Primary focus: elasticity and firmness
- Developed for skin that has lost elasticity
- Elastin as a key distinguishing active
- DMAE for structural skin support
EXOCODE RADIANCE-R (SEPARATE PRODUCT)
- Ampoule 2: Tranexamic Acid, Niacinamide, Dipotassium Glycyrrhizate, Palmitoyl Tetrapeptide-7, Nonapeptide-1
- Primary focus: radiance and skin tone
- Developed for dull, grey, or uneven-toned skin
- Tranexamic acid and niacinamide as key actives
- Brightening and melanin inhibition focus
Protocol Context
How EXOCODE Resilience - R Is Used
Step 1: Mix
Pour the contents of Ampoule 1 (EXOCODE Core Solution) into Ampoule 2 (EXOCODE Resilience-R Solution) and mix thoroughly. The combined volume is 5 ml per treatment.
Step 2: Apply
Apply an appropriate amount to the face and allow complete absorption. This is a topical application — not intradermal injection. Ensure the skin is clean and prepared for treatment.
Step 3: Device Compatibility
EXOCODE Resilience-R is documented as compatible with microneedle RF, Nd:YAG laser, and HIFU as adjunct energy-based device modalities. The specific integration protocol for each device type should follow manufacturer guidance and practitioner training.
Recommended course: 3 sessions spaced 3–4 weeks apart per ExoCoBio documentation. For professional clinic use by trained practitioners only.
Clinical Applications
Primary Clinical Use Cases
- •Skin elasticity loss and firmness reduction
- •Age-related skin laxity
- •Post-procedure skin quality support
- •Collagen and elastin support protocols
- •Combination with RF microneedling, HIFU, or Nd:YAG
Treatment Areas
- •Face (primary)
- •Neck and décolleté
- •Areas showing laxity or loss of firmness
EXOCODE Resilience-R vs Other Products in the Range
EXOCODE Resilience-R (Plant-Based)
- ExoCoBio — same manufacturer as ASCE+ SRLV
- Rosa Damascena plant exosomes via ExoSCRT™
- Six growth factors in core solution
- Topical application, not injectable
- Elastin as a primary distinguishing active
- Elasticity / firmness primary focus
ASCE+ SRLV (Human-Derived, Same Manufacturer)
- ExoCoBio — same ExoSCRT™ platform
- Human adipose stem cell-derived exosomes
- Published peer-reviewed RCT data (skin + microneedling)
- Post-microneedling or mesotherapy delivery
- Broader skin rejuvenation positioning
- Hydration, pore, firmness, dullness
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View ProductEXOCODE Resilience - R Questions
ExoCoBio Inc., Seoul, South Korea — the same company that makes ASCE+ SRLV and ASCE+ HRLV. ExoCoBio is a specialist exosome biotechnology company with one of the strongest exosome patent portfolios globally. EXOCODE is their plant-exosome product line, developed using the same ExoSCRT™ technology used for their human-derived ASCE+ range.
ExoSCRT™ is ExoCoBio's proprietary isolation and purification technology. Standard plant exosome products often use simple extraction from plant juice. ExoSCRT™ mass-cultures plant stem cells and then isolates high-purity exosomes from that culture — a more controlled, standardised process. ExoCoBio holds a US patent for their Rose Stem Cell-derived Exosome (RSCE™) technology, and the INCI name (Rosa Damascena Callus Extracellular Vesicles) is registered with the Personal Care Products Council in the US.
Ampoule 1 contains six recombinant growth factors alongside the Rosa Damascena exosomes: sh-Oligopeptide-1 (EGF), sh-Oligopeptide-2 (IGF-1), sh-Polypeptide-1 (bFGF), sh-Polypeptide-3 (KGF/FGF-7), sh-Polypeptide-4 (TGF-β1), and sh-Polypeptide-9 (VEGF). These are synthetic analogues of naturally occurring human growth factors, included to support cellular signalling, fibroblast activity, collagen synthesis, and skin vitality.
Resilience-R targets elasticity and firmness — developed for skin that has lost elasticity. Radiance-R targets dull, grey, or uneven-toned skin. Both share the same Ampoule 1 (Rosa Damascena exosomes + six growth factors). Their Ampoule 2 contents differ entirely. Resilience-R's Ampoule 2 contains elastin, DMAE, copper tripeptide-1, and Palmitoyl Pentapeptide-4 for elasticity. Radiance-R's Ampoule 2 contains tranexamic acid, niacinamide, and dipotassium glycyrrhizate for brightening and tone.
No. EXOCODE Resilience - R is a topical treatment. The two ampoules are mixed and the combined solution is applied to the skin surface and allowed to absorb. It is not formulated or indicated for intradermal injection. This distinguishes it from ASCE+ SRLV, which is used in post-microneedling topical and mesotherapy intradermal protocols.
Per ExoCoBio documentation, Resilience-R is compatible as an adjunct product alongside microneedle radiofrequency (RF), Nd:YAG laser, and HIFU. Specific application timing and protocol design for each device modality should follow the device manufacturer's guidelines and the treating practitioner's clinical judgment.