Human-Derived Hair & Scalp
Hairna Exosome Hair Filler
Human-derived exosome scalp booster by Maypharm Co., Ltd. 2.5 ml pre-filled syringe with adipose MSC exosomes for microneedling-assisted scalp delivery.
View Product Human-Derived Hair & Scalp Hycell
EXO ROOT
Professional two-step human-derived exosome scalp rejuvenation system, developed by Hycell (Seoul, South Korea). A lyophilised dual-vial format combining human dermal fibroblast-derived exosomes with 3% Ginseng Callus exosomes (freeze-dried at −80°C) in Vial 1, reconstituted with a Scalp Renew Solution containing 13 peptides, sodium hyaluronate, biotin, panthenol, caffeine, and Zinc PCA in Vial 2. Designed for scalp vitality, follicular environment support, and barrier restoration in professional aesthetic and trichology-adjacent clinic settings.
Professional use product. No exosome products are currently FDA-approved for any hair or scalp indication. All descriptions use professional and investigational framing only.
Product Overview
What Is EXO ROOT?
EXO ROOT is manufactured by Hycell, a Seoul-based Korean biotech company. It is their flagship product — the only product in the Hycell range at the time of writing, positioned explicitly as the first of multiple planned exosome-based products on their platform (exoroot.com).
The format follows the lyophilised dual-vial system used across the Korean professional exosome scalp range. Vial 1 contains the freeze-dried exosome powder: a blend of human dermal fibroblast-derived exosomes and 3% Ginseng Callus exosomes, freeze-dried at −80°C. Vial 2 is the Scalp Renew Solution: a concentrated 5 ml active formulation containing 13 named peptides (including 3 tripeptides and 10 growth factor polypeptides), sodium hyaluronate, biotin, panthenol, caffeine, and Zinc PCA. The two components are reconstituted immediately before use.
EXO ROOT's dual exosome source is the distinctive element: human dermal fibroblast-derived exosomes provide the primary cellular signalling payload, while the 3% Ginseng Callus exosomes add plant-origin phyto-growth factors and antioxidant properties. This hybrid approach — human-derived primary source with a botanical secondary component — places it in a different formulation category from pure human-derived products like Hairna, and from pure plant-based products like LXH Leuco Exo Hair.
Regulatory note: There are currently no FDA-approved exosome products. EXO ROOT is a professional aesthetic product for scalp care protocols. It is not a pharmaceutical and has not received FDA or equivalent drug approval as a treatment for alopecia or any hair loss condition. Hair and scalp claims carry the highest FDA enforcement risk in this category. All descriptions use investigational and professional framing only. For professional use by qualified practitioners.
Formulation & Product Characteristics
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Dual Exosome Complex — Human Fibroblast + 3% Ginseng Callus
Vial 1 contains two exosome sources working in combination. Human dermal fibroblast-derived exosomes provide the primary cellular communication and scalp tissue support payload. Ginseng Callus exosomes (3%, Panax ginseng stem cell culture) contribute natural phyto-growth factors and antioxidant properties. The powder is freeze-dried at −80°C to preserve biological activity until reconstitution.
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13-Peptide Complex in the Scalp Renew Solution
The Scalp Renew Solution carries 13 named peptides: Copper Tripeptide-1 (GHK-Cu), Biotinyl Tripeptide-1, Nicotinyl Tripeptide-1, and 10 recombinant growth factor polypeptides (sh-Decapeptide-9, sh-Polypeptide-1/bFGF, sh-Polypeptide-3/KGF, sh-Polypeptide-6, sh-Polypeptide-8, sh-Polypeptide-9/VEGF, sh-Polypeptide-22, sh-Polypeptide-59). This is the broadest peptide profile in the scalp range on this site.
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Caffeine + Zinc PCA — Scalp Microenvironment Support
Caffeine is included for follicular stimulation and scalp microcirculation support. Zinc PCA (Pyrrolidone Carboxylic Acid) regulates sebum production and provides antibacterial properties, supporting scalp microbiome balance and a healthy scalp environment. These actives are not present in the other human-derived scalp products in the range.
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Sodium Hyaluronate + Panthenol + Biotin
Sodium hyaluronate provides scalp moisture balance and hydration. Panthenol (Pro-Vitamin B5) calms post-procedure irritation, supports barrier repair, and improves scalp resilience. Biotin supports keratin infrastructure and hair structure. All three appear across the scalp range; their combination with the 13-peptide complex in a single Scalp Renew Solution is specific to EXO ROOT.
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Lyophilised at −80°C — Dual-Vial Format
Freeze-drying at −80°C preserves exosome structure, stability, and biological activity at a lower temperature than standard lyophilisation. The dual-vial format (lyophilised powder + concentrated active solution) is the standard for professional Korean exosome scalp products, requiring reconstitution immediately before use.
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Hycell, Seoul
Hycell is a Seoul-based Korean biotech company. EXO ROOT (exoroot.com) is their flagship product and the first in their planned exosome product range. The brand operates a dedicated professional distribution model. Contact: exoroot.com.
Range Context
EXO ROOT vs the Human-Derived Scalp Range
There are three human-derived exosome scalp products on the site. Understanding how they differ is useful for practitioners choosing between them:
How EXO ROOT Fits Professional Aesthetic Practice
EXO ROOT sits in the human-derived segment of the scalp range with a formulation profile that is broader in peptide depth than Hairna and more targeted toward the scalp microenvironment than ASCE+ HRLV Hair. The Caffeine + Zinc PCA combination addresses sebum balance and follicular stimulation specifically, making it well-suited to practitioners treating seborrheic scalp conditions alongside general follicular vitality concerns. The dual exosome source — human fibroblast plus botanical Ginseng Callus — is a positioning element that may appeal to practitioners looking for human-derived potency with plant-origin complementary actives.
Best-Fit Use Cases
- •MTS-assisted scalp vitality protocols
- •Sebum balance and scalp microbiome support
- •Post-scalp microneedling recovery
- •Follicular environment and barrier restoration
- •Combination with LLLT, PRP, or energy devices
- •Practitioners seeking broad peptide depth in a scalp product
Related Treatment Contexts
- •Korean professional scalp booster workflows
- •Human-derived exosome scalp protocols
- •Comparison with Hairna (adipose MSC, pre-filled syringe)
- •Comparison with ASCE+ HRLV Hair (ExoCoBio, plant-based)
- •Comparison with LXH Leuco Exo Hair (plant-based, CNB)
- •Trichology-adjacent professional clinic settings
Formulation
Active Ingredients — What's Actually in EXO ROOT
EXO ROOT uses the lyophilised dual-vial reconstitution format. Combine the Scalp Renew Solution (Vial 2) into the exosome powder (Vial 1) and mix until fully dissolved immediately before use.
Vial 1 — Lyophilised Exosome Powder (100 mg)
- •Human dermal fibroblast-derived exosomes: Primary exosome source. Cellular communication, scalp tissue support, and follicular microenvironment signalling payload.
- •Ginseng Callus exosomes (3%): Panax ginseng stem cell culture extracellular vesicles. Natural phyto-growth factors and antioxidant properties — the same Ginseng Callus source used in LXH Leuco Exo Hair and LXC Lacto Exo Colla (CNB International).
- •Freeze-drying temperature: −80°C — preserves structure, stability, and maximum biological activity until reconstitution.
Vial 2 — Scalp Renew Solution (5 ml)
- •Sodium hyaluronate: Scalp hydration and moisture balance.
- •Panthenol (Pro-Vitamin B5): Barrier repair, anti-inflammatory, post-procedure soothing.
- •Biotin: Vitamin B7 — keratin infrastructure and hair structure support.
- •Caffeine: Follicular stimulation and scalp microcirculation support.
- •Zinc PCA: Sebum regulation, antibacterial properties, scalp microbiome balance.
13 Peptides (confirmed from manufacturer documentation):
- ◦Copper Tripeptide-1 (GHK-Cu) — extracellular matrix synthesis, follicular cell proliferation, hair growth cycle regulation
- ◦Biotinyl Tripeptide-1 — keratinocyte proliferation, adhesion molecule synthesis, tissue recovery signalling
- ◦Nicotinyl Tripeptide-1 — niacinamide-based tripeptide, barrier and tone support
- ◦sh-Decapeptide-9 — follicular activity signalling
- ◦sh-Polypeptide-1 (bFGF) — fibroblast stimulation and collagen support
- ◦sh-Polypeptide-3 (KGF) — keratinocyte and epidermal repair
- ◦sh-Polypeptide-6 — growth factor polypeptide
- ◦sh-Polypeptide-8 — growth factor polypeptide
- ◦sh-Polypeptide-9 (VEGF) — vascularisation and follicular nutrient supply
- ◦sh-Polypeptide-22 — growth factor polypeptide
- ◦sh-Polypeptide-59 — growth factor polypeptide
- ◦Plus 2 further peptides — full list to verify with Hycell manufacturer documentation
Formulation note: Dual exosome complex, 13 peptide identities, and key actives confirmed from Hycell's own product page (exoroot.com) and independent reseller sources. Full INCI list and concentrations should be verified with Hycell manufacturer documentation before clinical use.
How Clinicians Use EXO ROOT
MTS (Micro-Needle Therapy System) — Primary Delivery
Reconstituted solution is applied to a clean, dry scalp and administered using MTS. The microchannel penetration window enhances delivery of the exosome complex, peptides, and supporting actives to the scalp dermis and follicular level. Recommended needle depth: 0.5–1.5 mm (practitioner-determined based on individual assessment).
Mesotherapy (Intradermal Injection)
The reconstituted solution may also be administered via intradermal mesotherapy injection for direct follicular-level delivery. Standard mesotherapy technique; needle gauge and depth per practitioner protocol.
Combination Protocols
Compatible with LLLT (low-level laser therapy), PRP, and scalp energy-based device protocols. The dual exosome complex, 13-peptide profile, and caffeine + zinc components make EXO ROOT suited to multi-modal programmes addressing both follicular environment and scalp microbiome concerns simultaneously.
Each box contains 5 sets (100 mg powder + 5 ml solution per set). Protocol frequency to be determined by the practitioner based on clinical assessment. Reconstitute immediately before use. Confirm with Hycell manufacturer guidelines and practitioner clinical judgment.
Specification Summary
Product Specification
Related Products
Other professional Korean exosome scalp and hair products.
Plant-Based Hair & Scalp
ASCE+ HRLV Hair
Plant-based scalp rejuvenation by ExoCoBio Inc. Rosa Damascena Callus EVs, 10B per vial, 598 miRNA types, 9 growth factor polypeptides, PRP-compatible.
View Product
Plant-Based Hair & Scalp
LXH Leuco Exo Hair
Plant-based scalp vitality product by CNB International. Triple exosome complex with PDRN 10,000 ppm for MTS-assisted scalp delivery protocols.
View ProductEXO ROOT Questions
Two sources combined in the lyophilised powder. Primary: human dermal fibroblast-derived exosomes, providing the cellular communication and scalp tissue support payload. Secondary: 3% Ginseng Callus exosomes (Panax ginseng stem cell culture), contributing phyto-growth factors and antioxidant properties. Freeze-dried at −80°C for maximum preservation of biological activity.
Different manufacturers, exosome sources, formats, and active profiles. EXO ROOT (Hycell) uses human dermal fibroblast exosomes plus 3% Ginseng Callus EVs in a dual-vial lyophilised system with 13 peptides, caffeine, and Zinc PCA. Hairna (Maypharm) uses adipose MSC exosomes (2xosome technology) in a pre-filled ready-to-use syringe with Biotinoyl Tripeptide-1, GHK-Cu, and FGF2. Both are human-derived but from different cell sources; both support scalp vitality in professional investigational contexts.
Both are human-derived scalp products but from different manufacturers with different technology platforms and formulation profiles. ASCE+ HRLV Hair (ExoCoBio) uses adipose MSC exosomes via ExoSCRT™ tangential flow filtration. EXO ROOT (Hycell) uses human fibroblast exosomes plus Ginseng Callus EVs, freeze-dried at −80°C. ASCE+ HRLV Hair's solvent emphasises growth factors, amino acids, and minerals. EXO ROOT's Scalp Renew Solution has a distinctive 13-peptide profile plus caffeine and Zinc PCA for sebum and microbiome support.
Caffeine is thought to support follicular stimulation and scalp microcirculation. In vitro and early-stage research has explored caffeine's potential to antagonise DHT-mediated inhibition of hair follicle cell proliferation. In a scalp booster context, it is included for microcirculation and follicular activity support. It is distinct from minoxidil and carries no drug approval for hair loss; its inclusion here is as an aesthetic professional scalp active, not a therapeutic agent.
Zinc PCA (Zinc Pyrrolidone Carboxylic Acid) regulates sebum production on the scalp, provides antibacterial properties, and supports scalp microbiome balance. It is particularly relevant for practitioners treating seborrheic scalp presentations or excess oil production alongside the follicular vitality protocol. It distinguishes EXO ROOT from the other human-derived scalp products in the range.
No. EXO ROOT does not carry FDA or equivalent regulatory approval as a treatment for alopecia or any hair loss condition. It is a professional scalp vitality and follicular environment support product for use in investigational aesthetic protocols. All professional communication must remain within investigational and scalp vitality framing.
EXO ROOT is available for professional clinic purchase and wholesale distribution orders. Contact Exosome Korea via the Contact / Wholesale page to discuss availability, pricing, and minimum order quantities.