Plant-Based Hair & Scalp
LXH Leuco Exo Hair
Plant-based scalp vitality product by CNB International. Triple exosome complex (Leuconostoc + Ginseng + Camellia) with PDRN 10,000 ppm. Professional MTS protocol use.
View Product Plant-Based Hair & Scalp ASCE+ Range
ASCE+ HRLV Hair
Plant-based exosome scalp rejuvenation product for professional hair and scalp care protocols, developed by ExoCoBio Inc. (Seoul, South Korea). A lyophilised single-vial system: 20 mg powder containing 10 billion Rosa Damascena Callus Extracellular Vesicles (ExoSCRT™ RSCE™ technology), 598 miRNA types, 1,008 proteins and growth factors, biotin 0.05%, 4 coenzymes, and 9 recombinant growth factor polypeptides — reconstituted with a scalp-targeted activator containing sodium hyaluronate and 19 amino acids. The second product in ExoCoBio's ASCE+ professional range, alongside ASCE+ SRLV for skin.
Professional use product. No exosome products are currently FDA-approved for any hair or scalp indication. All descriptions use professional and investigational framing only.
Product Overview
What Is ASCE+ HRLV Hair?
ASCE+ HRLV Hair is the second product in ExoCoBio's professional ASCE+ range, launched in April 2022. The first — ASCE+ SRLV — targets skin rejuvenation. HRLV targets the scalp and hair. Both use ExoCoBio's ExoSCRT™ isolation technology. HRLV is the hair-targeted iteration: higher exosome count per vial (10 billion vs. 5 billion in SRLV), a scalp-specific activator, and a formulation profile oriented toward the follicular environment and scalp health.
The lyophilised powder contains 598 miRNA types and 1,008 proteins and growth factors — significantly broader than SRLV's 96 miRNA types and 200+ proteins. The inclusion of 4 coenzymes (NAD+, FAD, thiamine diphosphate, Coenzyme A) and 9 recombinant growth factor polypeptides in the powder itself distinguishes the HRLV formulation from the skin range products. Biotin 0.05% is included directly in the lyophilised powder.
A distinctive protocol option: the reconstituted HRLV powder can be dissolved in PRP (platelet-rich plasma) rather than the standard activator, allowing the growth factors in platelets to further augment the exosome effect. This PRP combination workflow is unique to HRLV in the ASCE+ range.
Regulatory note: There are currently no FDA-approved exosome products. ASCE+ HRLV Hair is a professional aesthetic product for scalp care protocols. It is not a pharmaceutical and has not received FDA or equivalent drug approval as a treatment for alopecia or any hair loss condition. Hair and scalp claims carry the highest FDA enforcement risk. All descriptions use investigational and professional framing only. For professional use by qualified practitioners.
Range Context
The ASCE+ Range — SRLV vs HRLV
ASCE+ HRLV Hair and ASCE+ SRLV share the same manufacturer and isolation technology. The differences are in formulation depth and clinical target:
Formulation & Product Characteristics
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Rosa Damascena Callus Extracellular Vesicles — 10 Billion per Vial
The exosome source is Rosa Damascena (Damask rose) callus cultures, isolated using ExoCoBio's ExoSCRT™ proprietary tangential flow filtration process. HRLV contains 10 billion exosomes per vial — twice the concentration of ASCE+ SRLV (5 billion). ExoCoBio holds a US patent for this RSCE™ technology, with INCI registration at PCPC 2020.
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598 miRNA Types + 1,008 Proteins and Growth Factors
The lyophilised powder contains 598 miRNA types with anti-inflammatory activity and 1,008 types of proteins and growth factors supporting the hair growth cycle. This is the broadest molecular profile of any product in the ASCE+ range — SRLV carries 96 miRNA types and 200+ proteins.
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4 Coenzymes in the Lyophilised Powder
NAD+ (Nicotinamide Adenine Dinucleotide), FAD (Flavin Adenine Dinucleotide), Thiamine Diphosphate, and Coenzyme A are included directly in the lyophilised powder. These coenzymes support cellular energy metabolism and are included as part of the hair growth cycle support formulation.
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9 Recombinant Growth Factor Polypeptides
The powder contains 9 named sh-polypeptide and sh-oligopeptide growth factors: EGF (sh-Oligopeptide-1), IGF-1 (sh-Oligopeptide-2), sh-Oligopeptide-4, TGF-β1 (sh-Polypeptide-4), VEGF (sh-Polypeptide-9), sh-Polypeptide-13, sh-Polypeptide-8, bFGF (sh-Polypeptide-1), KGF (sh-Polypeptide-3).
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Biotin 0.05% — Included in Lyophilised Powder
Biotin (Vitamin B7) is incorporated directly into the exosome powder at 0.05%, supporting keratin infrastructure and scalp health as part of the lyophilised formulation rather than in the activator.
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PRP Compatibility — Unique Delivery Option
The HRLV powder can be dissolved in PRP (platelet-rich plasma) instead of the standard activator. The growth factors in platelets augment the exosome effect within the same injection session. This PRP combination protocol is explicitly noted in ExoCoBio's product documentation.
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Patent KR 10-2265875-0000 — Hair Colour Rejuvenation
ExoCoBio registered the world's first patent for a composition designed to rejuvenate hair colour (prevent premature greying) using stem cell-derived exosomes. This is the proprietary basis for HRLV's hair anti-ageing positioning alongside its scalp rejuvenation and follicular vitality focus.
How ASCE+ HRLV Fits Professional Aesthetic Practice
ASCE+ HRLV sits at the premium end of the plant-based scalp range. Its combination of high exosome concentration (10 billion), broad molecular profile (598 miRNAs, 1,008 proteins/GFs), PRP compatibility, and an ExoCoBio patent for hair colour rejuvenation gives practitioners a formulation with more depth than any other plant-based scalp product in the range. It shares the Rosa Damascena RSCE™ technology with EXOCODE Resilience-R and Radiance-R (topical skin products), but applies it at higher concentration to the scalp context with a hair-specific activator and coenzyme profile.
Best-Fit Use Cases
- •Scalp rejuvenation and follicular vitality protocols
- •MTS-assisted scalp exosome delivery
- •Mesotherapy intradermal scalp treatment
- •PRP combination scalp sessions
- •Post-procedure scalp recovery
- •Hair anti-ageing programmes (including greying)
Related Treatment Contexts
- •Korean plant-based exosome scalp workflows
- •Combination with LLLT, energy-based scalp devices
- •Comparison with LXH Leuco Exo Hair (CNB, plant-based)
- •Comparison with Hairna / EXO ROOT (human-derived scalp)
- •Practitioners already using ASCE+ SRLV for skin
- •Premium professional scalp rejuvenation programmes
Formulation
Complete INCI — What's Actually in ASCE+ HRLV Hair
ASCE+ HRLV uses a single lyophilised vial reconstituted with a separate activator solution immediately before use. The powder and activator are kept separate until the moment of application to preserve exosome bioactivity.
Lyophilised Powder (20 mg) — Full Verified INCI
Activator Solution — Verified INCI
Formulation note: Full INCI confirmed from multiple independent reseller sources cross-referenced against ExoCoBio published specifications. Growth factor identities (sh-polypeptide INCI to common name mapping) consistent with the ASCE+ SRLV and EXOCODE range verification. Full batch-specific INCI should be confirmed with ExoCoBio Inc. manufacturer documentation before clinical use.
How Clinicians Use ASCE+ HRLV Hair
Mesotherapy (Intradermal Scalp Injection) — Primary Delivery
Reconstituted solution administered intradermally into the scalp using standard mesotherapy technique. 30G or 32G needle, intradermal depth. Apply across the treatment zone. The exosomes, growth factors, and coenzymes deliver directly into the scalp dermis adjacent to hair follicles.
MTS (Micro-Needle Therapy System) — Topical Post-Microneedling
Applied topically immediately after scalp microneedling while microchannels are open. Allows penetration of the reconstituted solution past the scalp barrier. Compatible with standard MTS needle depths for scalp application (0.5–1.5 mm, practitioner-determined).
PRP Combination Protocol
The HRLV lyophilised powder can be reconstituted directly in PRP rather than the standard activator. Platelet-derived growth factors complement the Rosa EV signalling payload. This combination workflow is documented in ExoCoBio product materials and gives practitioners a premium single-session delivery option.
Combination with Energy-Based Devices
Compatible with scalp LLLT, RF microneedling, and other energy-based scalp device protocols. Apply in the same session or as an independent scalp booster programme. The ExoCoBio ASCE+ range is routinely used in combination with energy-based aesthetics across international clinic networks.
Recommended protocol: 3–5 sessions at 4-week intervals for an initial course, with maintenance sessions thereafter. Reconstituted vial: use within 24–48 hours of preparation (confirm with manufacturer specification). Store lyophilised powder at 2°C–8°C. Confirm protocol with manufacturer guidelines and practitioner clinical judgment.
Specification Summary
Product Specification
Related Products
The full ASCE+ range and plant-based scalp alternatives.
Human-Derived Skin Rejuvenation
ASCE+ SRLV
The skin rejuvenation counterpart in the same ASCE+ range by ExoCoBio. Human adipose-derived MSC exosomes, 5B per vial, multi-active solvent. Backed by Park et al. 2023 RCT.
View Product
Human-Derived Hair & Scalp
Hairna Exosome Hair Filler
Human-derived exosome scalp booster by Maypharm Co., Ltd. 2.5 ml pre-filled syringe for microneedling-assisted and mesotherapy scalp delivery.
View ProductASCE+ HRLV Hair Questions
Rosa Damascena Callus Extracellular Vesicles — Damask rose callus cultures, isolated using ExoCoBio's ExoSCRT™ tangential flow filtration process. This is the same RSCE™ (Rose Stem Cell Exosome) source used in EXOCODE Resilience-R and Radiance-R. It is plant-based, not human-derived. Some resellers and clinical papers have described it incorrectly as adipose or human stem cell-derived; the INCI is definitive.
Both use ExoCoBio's ExoSCRT™ isolation technology but from different source materials. ASCE+ SRLV uses human adipose-derived MSC exosomes for skin rejuvenation. HRLV uses Rosa Damascena Callus EVs and is the hair/scalp formulation with double the exosome concentration (10B vs 5B), far broader miRNA content (598 vs 96 types), a larger protein/GF payload (1,008 vs 200+), 4 coenzymes in the powder, biotin 0.05%, and compatibility with PRP reconstitution. They are built on the same technology platform applied to different clinical contexts.
Yes. The lyophilised powder can be dissolved directly in PRP rather than the standard activator solution. This allows the platelet-derived growth factors in PRP to complement the Rosa EV molecular payload within a single reconstituted injection. The PRP combination protocol is documented in ExoCoBio product materials and is a distinctive delivery option unique to HRLV in the ASCE+ range.
Different manufacturers, exosome sources, and formulation profiles. ASCE+ HRLV (ExoCoBio) uses Rosa Damascena callus EVs at 10 billion per vial with 598 miRNA types and 9 growth factor polypeptides, plus PRP compatibility. LXH Leuco Exo Hair (CNB International) uses a triple fermented/plant exosome complex (Leuconostoc + Ginseng + Camellia) at 4.5 billion per ml, with PDRN 10,000 ppm as the solvent backbone. Both are plant-based; different source types, different active profiles.
No. ASCE+ HRLV Hair does not carry FDA or equivalent regulatory approval as a treatment for alopecia or any hair loss condition. It is a professional aesthetic product for scalp care and hair anti-ageing support protocols. Hair and scalp claims carry the highest FDA enforcement risk. All professional communication must use investigational and scalp vitality framing only.
ASCE+ HRLV Hair is available for professional clinic purchase and wholesale distribution orders. Contact Exosome Korea via the Contact / Wholesale page to discuss availability, pricing, and minimum order quantities.