EXOXE
Human-derived amniotic stem cell exosome skin rejuvenation treatment, manufactured by Regenbogen Co., Ltd (South Korea). A dual-vial lyophilised system: 50 mg lyophilised exosome powder containing Hydrolyzed Collagen (886,000 ppm), Collagen (100,000 ppm), and Sodium Hyaluronate, reconstituted with a 5 ml Sterilised HA Solution. 6 billion exosome particles per set at 986,000 ppm. Produced using Regenbogen's IOT (Induction Of Trophic) proprietary isolation technology. Targets skin aging, wrinkles, uneven tone, dullness, barrier damage, and post-inflammatory presentations. Companion product to EXOXE Hair, which uses the same platform for scalp applications.
No FDA-approved exosome products currently exist. EXOXE is a professional aesthetic product — not a pharmaceutical. For professional use by qualified practitioners only. All descriptions use investigational and professional framing.
What Is EXOXE?
EXOXE is manufactured by Regenbogen Co., Ltd, a South Korean biotech company. The EXOXE brand covers two products: EXOXE (face/skin rejuvenation, this product) and EXOXE Hair (scalp and hair, a separate product on this site). Both use Regenbogen's amniotic stem cell exosome platform and share the same lyophilised powder INCI — the skin and hair products are differentiated by their reconstitution solutions and clinical positioning rather than the exosome source.
The exosomes are derived from amniotic stem cells using Regenbogen's proprietary IOT (Induction Of Trophic) technology. The IOT process is described by Regenbogen as a secretion induction technology that moves away from the standard simple separation/ultracentrifugation method, producing exosomes that are richer in regenerative factors due to a regulated medium composition approach. The result is amniotic stem cell exosomes described as virtually identical in structure and function to natural human exosomes.
The lyophilised powder is notably formulated with a very high concentration collagen matrix: Hydrolyzed Collagen at 886,000 ppm (88.6% by weight) and intact Collagen at 100,000 ppm (10%), alongside Sodium Hyaluronate. This collagen-dominant powder serves as the structural scaffold that encapsulates and preserves the amniotic exosome payload through freeze-drying. On delivery to the skin, it provides direct ECM collagen support alongside the exosome signalling payload. The Sterilised HA Solution (Aqua + Sodium Hyaluronate) is the reconstitution carrier.
Primary applications: skin aging and wrinkle reduction, uneven skin tone and brightening, barrier damage repair, post-inflammatory skin conditions, dullness, and skin firming. Also described as effective for acne-related presentations and atopic dermatitis support contexts — though the latter must be framed as aesthetic investigational use, not pharmaceutical treatment.
Regulatory note: There are currently no FDA-approved exosome products. EXOXE is a professional aesthetic product. It is not a pharmaceutical. For professional use by qualified practitioners only. All descriptions use investigational and professional framing.
EXOXE vs EXOXE Hair — The Regenbogen Platform
Both EXOXE products use the same amniotic stem cell exosome platform, the same lyophilised powder INCI, and the same Sterilised HA Solution. The distinction is clinical positioning and target area:
See the companion scalp product: EXOXE Hair →
Formulation & Product Characteristics
Amniotic Stem Cell Exosomes — IOT Technology, 986,000 ppm
Human amniotic stem cell exosomes isolated via Regenbogen's IOT (Induction Of Trophic) proprietary secretion induction technology. IOT regulates the cell culture medium composition to produce exosomes with a richer regenerative factor profile than standard ultracentrifugation methods. The result: amniotic stem cell exosomes at 986,000 ppm concentration, 6 billion particles per set.
Hydrolyzed Collagen 886,000 ppm + Collagen 100,000 ppm
The powder's collagen matrix constitutes approximately 98.6% of the formulation by weight. This exceptionally high collagen concentration serves as the structural scaffold that encapsulates and protects the exosome payload through lyophilisation. On delivery, it provides direct ECM collagen support at the point of injection or penetration, complementing the exosome signalling payload.
Amniotic Stem Cell Source — Youngest MSC Type
Regenbogen describes amniotic stem cells as the youngest mesenchymal stem cells. The amniotic membrane is a neonatal tissue source; amniotic MSC-derived exosomes are positioned as having a more potent regenerative profile than exosomes from adult tissue sources (adipose, fibroblast) due to the youth and activity level of the source cells.
Sterilised HA Solution — Simple Carrier
The 5 ml reconstitution solution is a clean Aqua + Sodium Hyaluronate system. Unlike products that load their solvent with peptides, vitamins, or growth factors (e.g., ASCE+ SRLV, Selastin Exo Plus), EXOXE's solution is intentionally minimal — the full active payload is in the powder. The HA provides the carrier vehicle and hydration component.
Anti-Melanin + Brightening Mechanism
Regenbogen specifically cites melanin production inhibition as a primary mechanism — EXOXE is described as hindering melanin production to improve skin tone. This brightening positioning distinguishes EXOXE from many other human-derived exosome skin products in the range that focus more exclusively on wrinkles, firmness, and barrier function.
Regenbogen Co., Ltd — EXOXE Brand
Regenbogen Co., Ltd is the manufacturer of both EXOXE and EXOXE Hair. Instagram: @exoxe_official. WhatsApp: +82 10 8961 8131. The EXOXE brand's positioning is 'changing the standards of exosome' through the IOT technology approach.
How EXOXE Fits Professional Practice
EXOXE sits in the human-derived exosome skin rejuvenation category alongside ASCE+ SRLV (ExoCoBio), Hanheal (BNC Global), and GTM Exomela. Its amniotic stem cell source is shared only with EXOXE Hair in this range. The high-concentration collagen matrix in the powder and the explicit brightening/anti-melanin positioning are the two most distinctive clinical features compared to the adipose MSC and fibroblast-derived alternatives.
Best-Fit Use Cases
- •Skin aging and wrinkle reduction protocols
- •Skin tone brightening and anti-melanin
- •Barrier damage repair and restoration
- •Post-inflammatory skin support
- •Dullness and radiance improvement
- •Skin firming and elasticity
Related Treatment Contexts
- •Comparison with ASCE+ SRLV (adipose MSC, ExoCoBio)
- •Comparison with Hanheal (fibroblast, BNC Global)
- •Comparison with GTM Exomela (fibroblast, skin + pigmentation)
- •Post-laser skin quality and tone programmes
- •Korean human-derived exosome skin booster workflows
- •Combination with HA or peptide-based skin boosters
Complete INCI — What's in EXOXE
EXOXE uses a dual-vial reconstitution system. Combine the HA Solution into the lyophilised exosome powder and shake until fully dissolved. Use immediately.
Vial 1 — Lyophilised Exosome Powder (50 mg)
Vial 2 — Sterilised HA Solution (5 ml)
Formulation note: The formal INCI for the lyophilised powder lists Hydrolyzed Collagen (886,000 ppm), Collagen (100,000 ppm), and Sodium Hyaluronate — the amniotic exosome content is expressed as the collagen fraction rather than as a separately named exosome INCI. This is the same documentation pattern seen in EXOXE Hair. The amniotic stem cell exosome content (986,000 ppm, 6 billion particles) is confirmed from the Regenbogen/EXOXE brand's own product documentation and authorised resellers. Full INCI should be confirmed with Regenbogen Co., Ltd manufacturer documentation before clinical use.
How Clinicians Use EXOXE
Mesotherapy (Intradermal Injection) — Primary Delivery
Reconstituted solution administered intradermally across the treatment area using standard mesotherapy technique. 30G or 32G needle, intradermal depth. Face, neck, and body applications. Use immediately after reconstitution.
Post-Microneedling Topical Application
Applied topically immediately after microneedling or MTS (Micro-Needle Therapy System) while microchannels are open. The collagen-loaded exosome solution penetrates to the dermal level via the temporary barrier disruption.
Post-Laser and Barrier Repair Protocols
The anti-inflammatory and barrier-repair properties of amniotic exosomes combined with the direct collagen support from the powder matrix make EXOXE suited for post-laser recovery, barrier restoration, and sensitive skin presenting after procedures.
Reconstitute immediately before use. Use immediately after reconstitution — use the full vial within the same treatment session. Suitable for all skin types. Confirm protocol with Regenbogen Co., Ltd product guidelines and practitioner clinical judgment.