EXOXE Hair
Human-derived amniotic stem cell exosome scalp treatment for professional hair and scalp rejuvenation, manufactured by Regenbogen Co., Ltd (South Korea). A dual-vial lyophilised system: 50 mg exosome powder containing Hydrolyzed Collagen (886,000 ppm), Collagen (100,000 ppm), Sodium Hyaluronate, and Trehalose, reconstituted with a 5 ml Sterilised HA Solution. The exosomes are highly purified human-origin vesicles secreted by amniotic stem cells. Five sets per box. Targets dermal papilla and endothelial cell proliferation, scalp microcirculation, and follicular environment support.
No FDA-approved exosome products currently exist. EXOXE Hair is a professional aesthetic product for scalp care protocols only — not a pharmaceutical or approved treatment for hair loss. For professional use by qualified practitioners only.
What Is EXOXE Hair?
EXOXE Hair is manufactured by Regenbogen Co., Ltd, a South Korean biotech company. Regenbogen's EXOXE brand covers two product types: the EXOXE Exosome for skin rejuvenation, and EXOXE Hair for scalp and hair. Both are built on the same human amniotic stem cell exosome platform — highly purified exosomes secreted by amniotic stem cells, which Regenbogen describes as closely resembling human natural exosomes in structure and function.
The format is a standard dual-vial lyophilised system: 50 mg exosome powder per vial, reconstituted with 5 ml Sterilised HA Solution. Five sets per box. The powder's published INCI is distinctive — it lists Hydrolyzed Collagen at 886,000 ppm and Collagen at 100,000 ppm as the primary actives alongside Sodium Hyaluronate and Trehalose, reflecting that the exosome payload is primarily expressed as a high-concentration collagen fraction. The HA Solution is a straightforward Aqua + Sodium Hyaluronate carrier.
The mechanism centres on dermal papilla and endothelial cell proliferation — the two cell populations most directly involved in hair follicle function and scalp vascular support respectively. Improved scalp blood circulation is a stated primary effect, which is the upstream condition for adequate follicular nutrient delivery.
Regulatory note: There are currently no FDA-approved exosome products. EXOXE Hair is a professional aesthetic product for scalp care protocols. It is not a pharmaceutical and has not received FDA or equivalent drug approval as a treatment for alopecia or any hair loss condition. Hair and scalp claims carry the highest FDA enforcement risk. All descriptions use investigational and professional framing only. For professional use by qualified practitioners.
EXOXE Skin vs EXOXE Hair — The Regenbogen Platform
Regenbogen Co., Ltd produces two products in the EXOXE range. Both use the same human amniotic stem cell exosome platform, with product-specific formulations for skin and scalp targets:
Formulation & Product Characteristics
Human Amniotic Stem Cell Exosomes
Highly purified exosomes secreted by human amniotic stem cells. Regenbogen describes these as closely resembling natural human exosomes in structure and function. The amniotic stem cell source is distinct from the adipose MSC source (Hairna, ASCE+ HRLV), dermal fibroblast sources (EXO ROOT, Hanheal), and plant sources (ASCE+ HRLV, LXH) used elsewhere in this range.
Hydrolyzed Collagen 886,000 ppm + Collagen 100,000 ppm
The lyophilised powder contains hydrolyzed collagen at the exceptionally high concentration of 886,000 ppm (88.6%) and intact collagen at 100,000 ppm (10%). This collagen complex forms the primary structural matrix of the powder alongside the exosomes, providing scalp and follicular dermis support at the point of delivery. The high collagen concentration is distinctive compared to other lyophilised exosome products in the range.
Sodium Hyaluronate (Powder + Solution) — Dual-HA Delivery
HA is present in both components: as a carrier in the lyophilised powder and as the primary active in the Sterilised HA Solution (Aqua + Sodium Hyaluronate). This dual-HA delivery provides scalp hydration support at the powder level and extended carrier hydration from the reconstitution solution.
Dermal Papilla + Endothelial Cell Proliferation
The primary stated mechanism: promotion of dermal papilla cell proliferation (the cells that direct hair follicle development and cycling) and endothelial cell proliferation (for scalp microvascular support). Improved scalp blood circulation is a downstream effect of the endothelial mechanism, improving nutrient and oxygen delivery to follicles.
5 Sets per Box — Dual-Vial Format
50 mg powder + 5 ml solution per set — 5 sets per box. Standard Korean lyophilised exosome dual-vial format. Reconstitute immediately before use. One set per session.
Regenbogen Co., Ltd — EXOXE Platform
Regenbogen is a South Korean biotech company. Their EXOXE platform covers both skin (EXOXE Exosome) and hair (EXOXE Hair) products using the same amniotic stem cell exosome source with product-specific formulations.
How EXOXE Hair Fits Professional Aesthetic Practice
EXOXE Hair sits in the human-derived scalp exosome segment alongside Hairna, EXO ROOT, Hanheal Hair Filler, and ASCE+ HRLV Hair. Its amniotic stem cell exosome source is the most distinctive positioning element — different from the adipose MSC source (Hairna), dermal fibroblast sources (EXO ROOT, Hanheal), and Rosa Damascena plant source (ASCE+ HRLV). The high-concentration collagen complex in the powder (886,000 ppm + 100,000 ppm) is also unique in the range.
Best-Fit Use Cases
- •Scalp vitality and follicular environment support
- •Dermal papilla cell activation protocols
- •Scalp microcirculation improvement
- •Post-procedure scalp recovery
- •Combination with other exosome or peptide scalp products
- •Practitioners looking for an amniotic-source exosome option
- •Trichology-adjacent professional clinic settings
Related Treatment Contexts
- •Korean human-derived exosome scalp workflows
- •Comparison with Hairna (adipose MSC, pre-filled syringe)
- •Comparison with EXO ROOT (fibroblast + Ginseng EVs)
- •Comparison with ASCE+ HRLV (Rosa EVs, plant-based)
- •Combination with Dermaheal HL or DR. CYJ Hair Filler
What's Actually in EXOXE Hair
EXOXE Hair uses the standard dual-vial lyophilised reconstitution format. Combine the HA Solution into the lyophilised powder vial and shake until fully dissolved immediately before use.
Lyophilised Powder (50 mg)
Formulation accuracy note: The exosome component of EXOXE Hair is listed in the INCI as the high-concentration Hydrolyzed Collagen and Collagen fractions rather than as a separately named exosome INCI. The manufacturer describes the product as containing "pure exo lyophilized powder" with amniotic stem cell exosomes, but the formal INCI does not include a named exosome ingredient. This is a known documentation pattern in this product category. The amniotic exosome content is stated by the manufacturer. Full INCI should be confirmed with Regenbogen Co., Ltd manufacturer documentation before clinical use.
Sterilised HA Solution (5 ml)
How Clinicians Use EXOXE Hair
Mesotherapy (Intradermal Injection) — Primary Delivery
Reconstituted solution administered intradermally across scalp treatment zones using standard mesotherapy technique. 30G or 32G needle, intradermal depth. One set (50 mg powder + 5 ml solution, reconstituted) per session.
Post-Microneedling Topical Application
Applied topically immediately after scalp microneedling while microchannels are open. The exosome and collagen complex penetrates to the scalp dermis via the temporary barrier disruption.
Combination Protocols
Compatible with Dermaheal HL (broad scalp nutrition), DR. CYJ Hair Filler (HA peptide depot), and LLLT in multi-modal scalp programmes. The amniotic exosome payload complements the biomimetic peptide mechanisms of the Caregen products.
Reconstitute immediately before use. One set per session. Session frequency to be determined by practitioner clinical judgment based on individual assessment. Confirm protocol with Regenbogen Co., Ltd manufacturer guidelines.