P198 ExoHealer Activating Solution
Professional exosome reconstitution solvent manufactured by Primoris International Co., Ltd (Gangnam-gu, Seoul, South Korea). The Filcore Activating Solution is the companion active solvent for the P198 ExoHealer Filcore SB lyophilised exosome powder system. Each 5 ml vial contains 59 skin-activating ingredients: 7 peptides, 22 amino acids, 13 vitamins, 4 minerals, hyaluronic acid, ubiquinone (CoQ10), and SOD antioxidant enzymes. 10 vials per box. Shelf life 36 months. Used with Filcore SB or SB Plus lyophilised exosome powder containing USC1994-CM™ umbilical cord blood stem cell conditioned media exosomes.
Product context: This page covers the Activating Solution — the reconstitution solvent component of the P198 ExoHealer system. The exosomes themselves are in the separate Filcore SB / SB Plus lyophilised powder (human-derived umbilical cord blood stem cell conditioned media). The solvent itself contains no exosomes; the system only delivers its full effect when both components are used together.
No FDA-approved exosome products currently exist. P198 ExoHealer products are professional aesthetic products — not pharmaceuticals. Claims on some reseller sites that these products are "FDA-cleared" or "CE-marked" are not supported by the product's actual regulatory documentation and should be disregarded. For professional use only.
What Is the P198 ExoHealer Activating Solution?
The P198 ExoHealer Activating Solution — formally the Filcore Activating Solution — is the reconstitution solvent component of Primoris International's ExoHealer system. Primoris International Co., Ltd is a South Korean biotech company with over 30 years of stem cell research starting from 1994. They describe themselves as one of the originators of exosome-based skin booster technology in Korea.
This solution's role is not simply a diluent. Primoris's product description specifies it is formulated as a pure stem cell culture medium — "100% stem cell culture without water" — that maximises skin absorption and active ingredient affinity. The 59 active ingredients it contributes are designed to synergise with the exosome payload in the companion Filcore SB powder, extending and amplifying the regenerative effect beyond what the exosomes alone would deliver.
The companion Filcore SB lyophilised powder contains Primoris's proprietary USC1994-CM™ exosomes — umbilical cord blood stem cell conditioned media preserved at −198°C. The SB standard contains 200,000 ppm USC1994-CM™; the SB Plus upgraded formulation contains 990,000 ppm with 6 additional growth factors (EGF, VEGF, IGF, KGF, GDF11, TIMP2). The Activating Solution is the same solvent for both powder versions.
Regulatory note: There are currently no FDA-approved exosome products. P198 ExoHealer products are professional aesthetic products. They are not pharmaceuticals and have not received FDA or equivalent drug regulatory approval. Claims on some reseller sites that these products are "FDA-cleared" or "CE-marked" are not supported by the product's actual regulatory documentation and should be disregarded. For professional use only.
Activating Solution in Context — The Filcore System
The P198 ExoHealer Activating Solution only delivers its full effect when used with the Filcore SB or SB Plus powder. Understanding the full system:
If the site is also stocking the Filcore SB or SB Plus exosome powder, those are separate products requiring their own pages. Confirm availability of the powder alongside the solvent when ordering.
Formulation & Product Characteristics
59 Active Ingredients — Pure Stem Cell Culture Medium
Primoris specifies the Activating Solution is formulated as "100% stem cell culture without water" — a concentrated active medium rather than a standard aqueous carrier. The 59 ingredients (7 peptides, 22 amino acids, 13 vitamins, 4 minerals, HA, ubiquinone, SOD enzymes) maximise skin absorption rate and active ingredient affinity when combined with the exosome powder.
7-Peptide Complex
Complex of 7 peptides included in the solvent to complement and amplify the exosome signalling payload from the Filcore SB powder. Specific peptide identities not disclosed in public documentation — confirm with Primoris International manufacturer documentation.
22 Amino Acids + 13 Vitamins — Full Cellular Nutrition Matrix
Full essential and non-essential amino acid profile covering 22 amino acids as building blocks for skin protein synthesis. 13-vitamin panel (consistent with a comprehensive cellular nutrition profile). This nutritional matrix supports cellular response to the exosome signals in the companion powder.
Hyaluronic Acid + Ubiquinone (CoQ10) + SOD Enzymes
HA for hydration and carrier support. Ubiquinone (Coenzyme Q10) for cellular energy and antioxidant protection. SOD (superoxide dismutase) antioxidant enzymes for reactive oxygen species neutralisation at the dermal level. These three together provide the antioxidant and hydration support layer within the solution.
USC1994-CM™ — Primoris's 30-Year Exosome Platform
The P198 designation refers to stem cell preservation at −198°C. USC1994-CM™ denotes Umbilical cord Stem Cell conditioned media, with 1994 marking the start of Primoris's stem cell research. Primoris claims 290+ SCI-level papers and international patents. The ExoHealer™ brand name specifically refers to the exosomes in USC1994-CM™.
5 ml × 10 Vials — High-Volume Clinic Format
10 vials per box provides a full 10-session supply for a clinic running one set per session. Each vial reconstitutes one Filcore SB or SB Plus powder vial. 36-month shelf life before opening.
How the P198 ExoHealer System Fits Professional Practice
The P198 ExoHealer system targets complex, composite skin problems rather than a single concern. Primoris's positioning is "skin self-sufficiency" — building the skin's own regenerative capacity through a combination of high-concentration umbilical cord blood stem cell exosomes and a comprehensive active solvent. The 59-ingredient Activating Solution is the vehicle that delivers the nutrient matrix necessary for the skin to respond to the exosome payload.
Best-Fit Use Cases
- •Complex composite skin problems (multi-concern)
- •Skin aging, fine lines, and elasticity protocols
- •Dullness, dryness, and inflammation support
- •Post-procedure skin repair and recovery
- •Premium human-derived exosome protocols
- •Clinics wanting a 30-year R&D-backed platform
Related Treatment Contexts
- •P198 ExoHealer brand professional workflows
- •Combination with Filcore SB or SB Plus powder
- •Comparison with ASCE+ SRLV (human-derived, different cell source)
- •Comparison with GTM Exomela (human-derived, skin + pigmentation)
- •Comparison with Hanheal Exosome Facial Rejuvenation
- •Post-microneedling exosome delivery protocols
59 Active Ingredients — Full Category Breakdown
All 59 ingredients are in the Activating Solution. The companion Filcore SB powder provides the exosome payload. Together they constitute the complete P198 ExoHealer system.
Formulation note: Active ingredient counts (7 peptides, 22 amino acids, 13 vitamins, 4 minerals, HA, ubiquinone, SOD) confirmed from the official Korean reseller listing (shineworld.kr) and multiple independent reseller sources. Individual peptide INCI names and vitamin identities are not disclosed in publicly available documentation. Full INCI list should be confirmed with Primoris International Co., Ltd manufacturer documentation before clinical use. The "59 active ingredients" total is consistent across all sources reviewed.
How Clinicians Use the P198 ExoHealer System
The Activating Solution is always used in combination with the Filcore SB or SB Plus lyophilised exosome powder. The protocol:
Reconstitution
Open the Filcore SB powder vial. Remove the rubber cap and add 5 ml of Activating Solution to the lyophilised exosome powder. Shake gently 3–4 times until fully dissolved. Use immediately.
Mesotherapy Injection
Administer the reconstituted solution intradermally using standard mesotherapy technique. The standard Filcore SB mix: 2 ml powder reconstituted with 5 ml Activating Solution (or alternatively with 3 ml normal saline + 2–2.5 ml HA — an alternative protocol noted by some resellers).
MTS / Microneedling Application
Apply to skin via MTS derma roller or derma pen immediately after microneedling. Apply the reconstituted solution to the treatment area and leave for 2–3 minutes to ensure full absorption.
After reconstitution, use immediately within the same treatment session. The active complex begins to degrade once in aqueous solution. Do not store reconstituted product for later use. Confirm full protocol with Primoris International product guidelines.