Hyalmass Aqua-Exosome
Triple-active hybrid skin booster for professional skin hydration and rejuvenation, distributed by Maypharm Co., Ltd and manufactured by Beauty Factory (South Korea). A pre-filled ready-to-use syringe (2.5 ml — 10 per box) combining 1% Hyaluronic Acid, exosomes at 4 billion particles per syringe (derived from both human stem cell-conditioned media and plant sources), and 0.01% PDRN. Three delivery routes: topical, post-microneedling, and mesotherapy injection. Not for use around the eyes. Face, neck, and décolleté indicated. Launched December 2024.
Product category note: Hyalmass Aqua-Exosome is a skin rejuvenation product, not a hair/scalp product. The exosome source is dual — human stem cell-conditioned media and plant-derived — which places it in a hybrid category. The human-derived component is primary. This is the only product in the Exosome Korea range that combines both human-derived and plant-derived exosome sources in a single formulation.
No FDA-approved exosome products currently exist. Hyalmass Aqua-Exosome is a professional aesthetic product — not a pharmaceutical. Evidence for the specific triple-active combination (HA + PDRN + exosomes) in a single formulation is at an early investigational stage. For professional use only.
What Is Hyalmass Aqua-Exosome?
Hyalmass Aqua-Exosome is distributed globally by Maypharm Co., Ltd and manufactured by Beauty Factory, a GMP-certified Korean medical aesthetics company. Beauty Factory developed the product using their proprietary HALO manufacturing technology, informed by partnerships with KINS Lab at Seoul National University and the Biomaterial Synthesis Lab at Sookmyung University. The global launch was December 2024.
The product's positioning is "hybrid mesotherapy filler" — a description that reflects its triple-active combination of HA, exosomes, and PDRN in a single ready-to-use syringe. Conventional HA skin boosters (Profhilo, Juvéderm Hydrate, Jalupro) deliver hydration without cellular regeneration signals. PDRN mesotherapy products deliver tissue repair without hydration scaffolding. Pure exosome products deliver cellular communication without immediate hydration. Hyalmass positions itself as addressing all three simultaneously.
The exosome source is dual — the Maypharm PRNewswire press release specifies exosomes derived from "human stem cell-conditioned media and plants." This is the only product in the range that explicitly combines both human-derived and plant-derived exosome sources in a single formulation.
The pre-filled syringe format (10 × 2.5 ml per box, 25 ml total) is designed for high-volume clinic use. No reconstitution is required. Three delivery routes are supported: topical, microneedling-assisted, and mesotherapy injection — more flexible than most products in the range.
Regulatory note: There are currently no FDA-approved exosome products. Hyalmass Aqua-Exosome is a professional aesthetic product. It is not a pharmaceutical. Evidence for the specific triple-active combination (HA + PDRN + exosomes) in a single formulation is at an early investigational stage. Established evidence bases exist separately for HA, PDRN, and exosomes individually. For professional use only.
Maypharm + Beauty Factory — Production Architecture
Maypharm Co., Ltd is the brand distributor responsible for global commercialisation. Beauty Factory is the contract manufacturer responsible for production. This is a common architecture in Korean aesthetic product development: a brand company manages R&D direction, distribution, and regulatory navigation; a specialist manufacturer produces the product under GMP.
Beauty Factory's HALO manufacturing technology is their proprietary process for producing the HA + PDRN + exosome formulation. The academic partnerships (Seoul National University's KINS Lab, Sookmyung University's Biomaterial Synthesis Lab) and international R&D collaborations in Poland and Germany are cited by Beauty Factory in the PRNewswire launch press release. Maypharm is also the distributor of Hairna Exosome Hair Filler and Hairna Exosome Booster Ampoule on this site, making them a multi-product partner brand.
Important distinction — two Maypharm manufacturing setups on this site:
- •Hairna Exosome Hair Filler / Booster Ampoule: Manufactured by Maypharm in-house using their 2xosome technology (adipose MSC exosomes)
- •Hyalmass Aqua-Exosome: Manufactured by Beauty Factory using HALO technology (dual-source exosomes). Maypharm is the distributor, not the manufacturer for this product.
Formulation & Product Characteristics
Triple-Active System — HA + PDRN + Dual-Source Exosomes
Three ingredient categories in one pre-filled ready-to-use syringe: 1% HA for immediate hydration, 4 billion exosomes per syringe (human stem cell-conditioned media + plant-derived) for cellular communication and regeneration, and 0.01% PDRN for tissue repair signalling through A2A adenosine receptor activation on fibroblasts. No reconstitution — open and use.
1% Hyaluronic Acid — Hydration Scaffold
HA at 1% provides the immediate hydration component of the formulation. High-purity, high-molecular-weight raw materials are specified in the Maypharm launch press release. HA binds water and provides the dermal volume support component of the triple-active system.
Dual-Source Exosomes — Human Stem Cell-Conditioned Media + Plant
The exosome component comes from two sources, per Maypharm's own PRNewswire press release: human stem cell-conditioned media and plant-derived exosomes. The specific cell type for the human-derived component and the plant source are not specified in publicly available documentation — confirm with Maypharm/Beauty Factory manufacturer documentation.
PDRN 0.01% — Fibroblast A2A Receptor Signalling
PDRN (polydeoxyribonucleotide) at 0.01% activates A2A adenosine receptors on fibroblasts, promoting collagen and elastin synthesis, tissue repair, and anti-inflammatory activity. This is the established PDRN mechanism documented across the Korean professional aesthetic literature.
Pre-Filled Syringe — Three Delivery Routes
Ready-to-use 2.5 ml syringe; no reconstitution. Three supported protocols: topical (1 ml morning + 1 ml evening), microneedling-assisted (1 syringe per session at 3-week intervals), and mesotherapy injection (3 sessions at 3–5 week intervals). Not for use around the eyes.
10 × 2.5 ml per Box — High-Volume Format
25 ml total volume per box. Designed for high-volume clinic workflows running multiple patients per session. Lower per-mL cost compared to single-vial formats.
How Hyalmass Aqua-Exosome Fits Professional Practice
Hyalmass positions itself at the intersection of HA skin booster, PDRN mesotherapy, and exosome biorevitalisation — three well-established Korean professional aesthetic categories that are usually addressed by separate products. Practitioners who currently run HA boosters or PDRN mesotherapy courses alongside exosome products may see Hyalmass as a workflow consolidation option.
Best-Fit Use Cases
- •Skin hydration and radiance protocols (face)
- •Skin elasticity and anti-ageing programmes
- •Combination hydration + regeneration in single session
- •Post-procedure skin recovery and barrier support
- •Neck and décolleté rejuvenation
- •High-volume clinic skin booster sessions
Related Treatment Contexts
- •Korean hybrid mesotherapy booster workflows
- •HA + PDRN combination practitioners
- •Post-laser or post-peel recovery support
- •Skin quality preparation before dermal filler
- •Comparison with pure HA boosters (Juvéderm Hydrate, Profhilo)
- •Comparison with standalone PDRN or exosome products
Active Ingredients — Confirmed Specification
Formulation note: HA 1%, exosome concentration (0.01 mg/mL = 4 billion/syringe), and PDRN 0.01% confirmed from fillerhouse.com and multiple independent reseller sources cross-referenced against Maypharm's official product page. Dual exosome source (human stem cell-conditioned media + plant) confirmed from Maypharm's PRNewswire launch press release. Specific human cell type and plant source are not specified in public documentation — confirm with Beauty Factory/Maypharm manufacturer documentation before clinical use.
How Clinicians Use Hyalmass Aqua-Exosome
Mesotherapy Injection — 3 Sessions × 3–5 Week Intervals
Standard mesotherapy technique. Inject intradermally across the treatment area (face, neck, décolleté). Pre-filled syringe; attach needle and inject. Three sessions at 3–5 week intervals for the initial course. Not for use around the eyes.
Microneedling-Assisted — 1 Syringe per Session × 3-Week Intervals
Apply the syringe contents across the treatment area during or immediately after microneedling while microchannels are open. One 2.5 ml syringe per session at 3-week intervals. The ready-to-use format speeds up the clinical workflow.
Topical Application — Morning + Evening at Home
The most unusual protocol for a product in this range: 1 ml applied topically in the morning and 1 ml in the evening. The pre-filled syringe dispenses a measured dose for direct skin surface application. This home-care topical route is in addition to professional clinic delivery options.
Application area: face, neck, décolleté. Do not apply around the eyes. Store in a cool, dry place away from direct sunlight. Confirm full protocol details with Maypharm / Beauty Factory product guidelines.