BotanicExo Mesotherapy
Plant-based exosome mesotherapy for professional skin rejuvenation, brightening, and anti-aging, manufactured by SpheBio Co., Ltd (Pohang-si / Seoul, South Korea). A dual-vial lyophilised system: 50 mg exosome powder containing LEXosome™ (Lithospermum erythrorhizon-derived plant exosomes) reconstituted with a 5 ml Active Solution carrying botulinum polypeptide, amino acids, vitamins, peptides, Shikonin, glutathione, and hyaluronic acid. 5 sets per box. EU CPNP/SCPN notified, FDA MoCRA registered, Vegan certified. Unique in the range for its Lithospermum erythrorhizon source and Shikonin active.
Clarification: The "botulinum polypeptide" in the Active Solution is a synthetic, INCI-registered cosmetic peptide (an Argireline-adjacent neuromodulating peptide). It is not botulinum toxin, not Botox, and is not an injectable toxin product.
No FDA-approved exosome products currently exist. BotanicExo Mesotherapy is a cosmetic product with EU CPNP/SCPN notification and FDA MoCRA cosmetic registration — these are cosmetic product notifications, not drug approvals or treatment authorisations. For professional use only.
What Is BotanicExo Mesotherapy?
BotanicExo Mesotherapy is manufactured by SpheBio Co., Ltd, a South Korean biotechnology company headquartered in Pohang-si, Gyeongsangbuk-do with R&D facilities in Gangnam-gu, Seoul. SpheBio's flagship product is BotanicExo; their product range also includes BotanicShine (a different plant exosome product). The CEO is Keun Sun Ahn; business registration 264-88-01988.
The exosome source is Lithospermum erythrorhizon — red-rooted sage (also called gromwell) — from which SpheBio produces their trademarked LEXosome™ (Lithospermum Erythrorhizon exosome) using their proprietary 3D Tissue Culture Platform. Lithospermum erythrorhizon is a traditional medicinal plant with a documented active compound, Shikonin, which is a naphthoquinone pigment with anti-melanogenic, anti-inflammatory, anti-glycation, and wound healing properties. Both the exosome source and the Shikonin active are distinct from any other product in the range.
The Active Solution contains a botulinum polypeptide — a synthetic peptide that mimics certain aspects of botulinum toxin's neuromodulating mechanism without containing actual botulinum toxin. This is an Argireline-adjacent class of peptide used in topical and mesotherapy-delivered formulations for expression line softening. It is not the same as Botox or any botulinum toxin injectable product.
BotanicExo Mesotherapy is the most extensively certified product in this range: CPNP/SCPN registered in the EU (cosmetic product notification, numbers 4547663 and 54963709), FDA MoCRA registered (No. 53-871320-044337), and Vegan certified (C839-001). These are cosmetic regulatory notifications, not drug approvals.
Regulatory note: There are currently no FDA-approved exosome products. BotanicExo Mesotherapy is a cosmetic product with EU CPNP/SCPN notification and FDA MoCRA cosmetic registration. These are cosmetic product notifications, not drug approvals or treatment authorisations. It is not a pharmaceutical. Botulinum polypeptide in the Active Solution is a synthetic peptide, not botulinum toxin. For professional use only.
Formulation & Product Characteristics
LEXosome™ — Lithospermum Erythrorhizon Exosomes, 3D Tissue Culture
SpheBio's proprietary plant exosome source derived from Lithospermum erythrorhizon (red-rooted sage/gromwell). Produced using SpheBio's 3D Tissue Culture Platform — a three-dimensional cell culture system described as producing higher-quality exosomes than standard 2D culture. LEXosome™ is the only Lithospermum-derived exosome source in this product range.
Shikonin — The Lithospermum-Specific Phytoactive
Shikonin is a naphthoquinone compound naturally present in Lithospermum erythrorhizon roots. Its documented biological activities relevant to skincare: (1) anti-melanogenic — inhibits melanin synthesis and tyrosinase activity; (2) anti-inflammatory — NF-κB pathway modulation; (3) anti-glycation — reduces AGE (advanced glycation end-product) formation that contributes to skin aging; (4) wound healing — activates keratinocyte migration. Shikonin is specific to this plant source and is not found in CICA, Ginseng, Rosa, or other exosome product sources in the range.
Botulinum Polypeptide — Synthetic Neuromodulating Peptide
A synthetic polypeptide mimicking aspects of botulinum toxin's neuromodulating mechanism. Inhibits SNARE complex assembly and neuromuscular signalling to reduce muscle contraction intensity — the peptide mechanism for expression line softening. This is not botulinum toxin or any toxin product; it is an INCI-registered cosmetic peptide. Acetyl Hexapeptide-8 (Argireline) is the most well-known peptide in this class.
Anti-Melanogenic + Anti-Glycation — Dual Anti-Aging Mechanisms
Most exosome products in the range address collagen synthesis, barrier function, or tissue repair. BotanicExo's combination of LEXosome™ + Shikonin specifically addresses two distinct aging pathways: melanin overproduction (hyperpigmentation, uneven tone) and glycation (AGE-induced collagen crosslinking and skin stiffening). The glycation mechanism is unique in the range.
EU CPNP/SCPN + FDA MoCRA + Vegan Certified
CPNP/SCPN: EU Cosmetic Products Notification Portal (EU cosmetic regulatory submission, not a drug approval). FDA MoCRA: US Modernization of Cosmetics Regulation Act registration (cosmetic product listing, not drug clearance). Vegan certification: C839-001. BotanicExo Mesotherapy is the most comprehensively notified cosmetic product in this range across multiple regulatory frameworks.
Shelf Life 24 Months — Storage 2–8°C
Standard professional lyophilised exosome product storage specification. Use immediately after reconstitution — do not store diluted product.
How BotanicExo Mesotherapy Fits Professional Practice
BotanicExo Mesotherapy addresses three mechanisms simultaneously that most products in the range cover individually: cellular regeneration (exosome signalling), pigmentation/brightening (Shikonin + anti-melanogenic pathway), and expression line softening (botulinum polypeptide). The anti-glycation positioning is unique in the range.
Best-Fit Use Cases
- •Anti-aging and wrinkle reduction protocols
- •Hyperpigmentation and uneven tone correction
- •Anti-glycation skin rejuvenation
- •Wound healing support (post-procedure)
- •Hair and scalp applications (dual use)
- •Brightening programmes with exosome synergy
Related Treatment Contexts
- •Plant-based exosome skin booster workflows
- •Comparison with EXOCODE Radiance-R (Rosa EVs, tone focus, topical)
- •Comparison with GTM Exomela (human-derived, tone focus)
- •Post-laser brightening and repair combined
- •Practitioners seeking vegan-certified professional products
- •Combination with MTS or microneedling
Complete INCI — What's in BotanicExo Mesotherapy
Dual-vial system. Add the Active Solution (Ampoule 2) to the lyophilised powder (Ampoule 1) and dissolve completely. Use immediately. Do not store reconstituted product.
Ampoule 1 — LEXosome™ Lyophilised Powder (50 mg)
Ampoule 2 — Active Solution (5 ml)
Formulation note: LEXosome™ source, Shikonin, botulinum polypeptide, and key active categories confirmed from fillerskorea.com, solvemedics.com, and the official SpheBio product page (en.sphebio.com). Specific amino acid, vitamin, and peptide INCI identities are not disclosed in publicly available documentation — confirm with SpheBio Co., Ltd (info@sphebio.com) before clinical use.
How Clinicians Use BotanicExo Mesotherapy
Mesotherapy Injection
Standard intradermal mesotherapy injection. Administer by a medical professional or dermatologist per product requirement. Face, neck, and hair/scalp applications (dual use confirmed).
MTS / Microneedling
Apply reconstituted solution via MTS or derma pen immediately after microneedling. Effective for the delivery of LEXosome™ and Shikonin to the dermal level.
Hair and Scalp Application
Korean Fillers and other resellers confirm scalp/hair follicle application is a supported use — consistent with the plant exosome platform's hair follicle activity citation. For mesotherapy delivery to the scalp. Skin rejuvenation remains the primary positioning.
Treatment interval: standard MTS/mesotherapy protocol. Storage: 2–8°C (unopened). Shelf life: 24 months. Reconstituted product: use immediately, do not store. Contraindications: hypersensitivity to any component; pregnancy or lactation; active skin infections or inflammation at treatment site; caution in autoimmune disorders.
CPNP, MoCRA & Vegan Certification
BotanicExo Mesotherapy holds the most comprehensive cosmetic regulatory notification profile of any product in the range:
Regulatory context: CPNP/SCPN registration means SpheBio has notified EU authorities that this cosmetic product meets EU cosmetics safety requirements. FDA MoCRA registration means the product has been listed with the FDA as a cosmetic product. Neither constitutes drug approval, medical device clearance, or evidence that the product has been evaluated for efficacy by a regulatory body. These are cosmetic regulatory compliance submissions.